PAPER Barbosa R, Midão L, Almada M, Costa E
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PAPER Croll PH, Vernooij MW, Reid RI, Goedegebure A, Power MC, Rigters SC, Sharrett AR, de Jong RJ, Mosley TH, de Groot M, Lin FR, Deal JA
Hearing loss and microstructural integrity of the brain in a dementia-free older population.
Alzheimers Dement. 2020 Nov;16(11):1515-1523. Epub 2020 Aug 2 PubMed: 32743902PAPER Rao SS, Portbury SD, Lago L, Bush AI, Adlard PA
The Iron Chelator Deferiprone Improves the Phenotype in a Mouse Model of Tauopathy.
J Alzheimers Dis. 2020;77(2):753-771. PubMed: 32741833Rudy Tanzi, William Eimer on Can an Antibody Allele Boost Your Alzheimer’s Risk By Giving Herpes an Edge?
COMMENT In this study, Pandey et al. report that a γ marker (GM) allotype more susceptible to HSV-1 immune evasion mechanisms is present at higher rates in subjects with Alzheimer’s disease. The authors show that carriers homozygous for the GM 17 allotype were si
Can an Antibody Allele Boost Your Alzheimer’s Risk By Giving Herpes an Edge?
RESEARCH NEWS 2020-08-04 Research News The idea that herpes simplex virus type 1 (HSV-1) stokes the fires of Alzheimer’s disease has gained traction in recent years. If true, how would such a common infection trigger neurodegenerative disease in some people, but not others? A stu
PAPER Calonga-Solís V, Malheiros D, Beltrame MH, Vargas LB, Dourado RM, Issler HC, Wassem R, Petzl-Erler ML, Augusto DG
Unveiling the Diversity of Immunoglobulin Heavy Constant Gamma (IGHG) Gene Segments in Brazilian Populations Reveals 28 Novel Alleles and Evidence of Gene Conversion and Natural Selection.
Front Immunol. 2019;10:1161. Epub 2019 Jun 4 PubMed: 31214166PAPER Ndjamen B, Farley AH, Lee T, Fraser SE, Bjorkman PJ
The herpes virus Fc receptor gE-gI mediates antibody bipolar bridging to clear viral antigens from the cell surface.
PLoS Pathog. 2014 Mar;10(3):e1003961. Epub 2014 Mar 6 PubMed: 24604090PAPER Atherton A, Armour KL, Bell S, Minson AC, Clark MR
The herpes simplex virus type 1 Fc receptor discriminates between IgG1 allotypes.
Eur J Immunol. 2000 Sep;30(9):2540-7. PubMed: 11009087PAPER Lubinski JM, Lazear HM, Awasthi S, Wang F, Friedman HM
The herpes simplex virus 1 IgG fc receptor blocks antibody-mediated complement activation and antibody-dependent cellular cytotoxicity in vivo.
J Virol. 2011 Apr;85(7):3239-49. Epub 2011 Jan 12 PubMed: 21228231PAPER Sprague ER, Wang C, Baker D, Bjorkman PJ
Crystal structure of the HSV-1 Fc receptor bound to Fc reveals a mechanism for antibody bipolar bridging.
PLoS Biol. 2006 Jun;4(6):e148. Epub 2006 May 2 PubMed: 16646632PAPER Frank I, Friedman HM
A novel function of the herpes simplex virus type 1 Fc receptor: participation in bipolar bridging of antiviral immunoglobulin G.
J Virol. 1989 Nov;63(11):4479-88. PubMed: 2552134Lancet Commission’s Dementia Hit List Adds Alcohol, Pollution, TBI
CONFERENCE COVERAGE 2020-08-04 Conference Coverage At this year’s virtual Alzheimer’s Association International Conference, researchers presented an update to “Dementia prevention, intervention, and care,” the 2017 report commissioned by The Lancet. Published July 30, the new report id
PAPER Livingston G, Huntley J, Sommerlad A, Ames D, Ballard C, Banerjee S, Brayne C, Burns A, Cohen-Mansfield J, Cooper C, Costafreda SG, Dias A, Fox N, Gitlin LN, Howard R, Kales HC, Kivimäki M, Larson EB, Ogunniyi A, Orgeta V, Ritchie K, Rockwood K, Sampson EL, Samus Q, Schneider LS, Selbæk G, Teri L, Mukadam N
Dementia prevention, intervention, and care: 2020 report of the Lancet Commission.
Lancet. 2020 Aug 8;396(10248):413-446. Epub 2020 Jul 30 PubMed: 32738937Eerdunfu Eerdunfu
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