RESEARCH NEWS 2019-08-16 Research News ApoE4 predisposes people to Alzheimer’s disease by modulating astrocytes and microglia, suggest researchers led by Julia TCW and Alison Goate at the Icahn School of Medicine at Mount Sinai, New York. In a preprint on bioRχiv, the researchers
PAPER Fessler MB
Pharmacol Ther. 2018 Jan;181:1-12. Epub 2017 Jul 16 PubMed: 28720427
PAPER Camargo N, Goudriaan A, van Deijk AF, Otte WM, Brouwers JF, Lodder H, Gutmann DH, Nave KA, Dijkhuizen RM, Mansvelder HD, Chrast R, Smit AB, Verheijen MH
PLoS Biol. 2017 May;15(5):e1002605. Epub 2017 May 26 PubMed: 28549068
RESEARCH MODELS Summary App NL-G-F /MAPT double knock-in mice represent a unique model for studying the nexus between human Aβ and human tau. These mice were created by crossing App NL-G-F mice with MAPT knock-in mice. In the former line, the endogenous mouse App gene wa
RESEARCH MODELS Summary It has been suggested that differences in mouse and human tau may partially underlie the difficulty in modeling Alzheimer’s disease in mice (see Alzforum webinar). In this knock-in model, the entire genomic sequence of murine Mapt from exon 1 to e
Columbia UniversityNew York City, United States
PAPER Tiwari S, Atluri V, Kaushik A, Yndart A, Nair M
Int J Nanomedicine. 2019;14:5541-5554. Epub 2019 Jul 19 PubMed: 31410002
PAPER Kreilaus F, Guerra S, Masanetz R, Menne V, Yerbury J, Karl T
Genes Brain Behav. 2020 Feb;19(2):e12604. Epub 2019 Sep 10 PubMed: 31412164
PAPER Chiò A, Moglia C, Canosa A, Manera U, Vasta R, Brunetti M, Barberis M, Corrado L, D'Alfonso S, Bersano E, Sarnelli MF, Solara V, Zucchetti JP, Peotta L, Iazzolino B, Mazzini L, Mora G, Calvo A
Neurology. 2019 Sep 3;93(10):e984-e994. Epub 2019 Aug 13 PubMed: 31409738
PAPER Ojelade SA, Lee TV, Giagtzoglou N, Yu L, Ugur B, Li Y, Duraine L, Zuo Z, Petyuk V, De Jager PL, Bennett DA, Arenkiel BR, Bellen HJ, Shulman JM
Cell Rep. 2019 Aug 13;28(7):1799-1813.e5. PubMed: 31412248
PAPER Zhang YS, Onishi AC, Zhou N, Song J, Samra S, Weintraub S, Fawzi AA
Invest Ophthalmol Vis Sci. 2019 Aug 1;60(10):3527-3536. PubMed: 31412112
PAPER Wang L, Zhao J, Wang CT, Hou XH, Ning N, Sun C, Guo S, Yuan Y, Li L, Hölscher C, Wang XH
CNS Neurosci Ther. 2019 Aug 14; PubMed: 31411808
PAPER Dede HÖ, Benbir Senel G, Karadeniz D
Acta Neurol Scand. 2019 Dec;140(6):399-404. Epub 2019 Sep 8 PubMed: 31411727
PAPER Hoang VH, Ngo VT, Cui M, Manh NV, Tran PT, Ann J, Ha HJ, Kim H, Choi K, Kim YH, Chang H, Macalino SJ, Lee J, Choi S, Lee J
J Med Chem. 2019 Sep 12;62(17):8011-8027. Epub 2019 Aug 27 PubMed: 31411468
PAPER Legdeur N, Tijms BM, Konijnenberg E, den Braber A, Ten Kate M, Sudre CH, Tomassen J, Badissi M, Yaqub M, Barkhof F, van Berckel BN, Boomsma DI, Scheltens P, Holstege H, Maier AB, Visser PJ
J Gerontol A Biol Sci Med Sci. 2019 Aug 14; PubMed: 31411322