Bernard Hanseeuw

Cliniques Universitaires Saint-Luc and Massachusetts General Hospital
Brussels, Belgium

Parsing Local and Distal Aβ Shows Links to Metabolism, Cognition

RESEARCH NEWS 2019-06-14 Research News For decades, researchers have wondered why Aβ deposits in the brain correlate poorly with local neural activity and cognition. Perhaps the correlation was not that weak, after all. A study in the June 4 Nature Communications suggests that it

David Jones on Parsing Local and Distal Aβ Shows Links to Metabolism, Cognition

COMMENT This is an interesting study that is trying to address an important apparent spatiotemporal paradox that arises when researchers try to reconcile large-scale spatial and temporal patterns associated with AD physiology and small-scale molecular events occu

PAPER van den Heuvel MP, Sporns O

A cross-disorder connectome landscape of brain dysconnectivity.

Nat Rev Neurosci. 2019 May 24; PubMed: 31127193

Marcus Raichle on Parsing Local and Distal Aβ Shows Links to Metabolism, Cognition

COMMENT This is a very interesting paper. One of the intriguing features of AD is the anatomy of the human brain that is vulnerable. I believe that a reasonable consensus is that it involves the hippocampus and the default mode network, which has been characteriz

Sliced by ApoE Genotype, Whole Exome Data Yield New AD Variants

RESEARCH NEWS 2019-06-14 Research News Does the head honcho of genetic Alzheimer’s risk occlude contributions of smaller genes? In the June 10 JAMA Neurology, researchers led by Lindsay Farrer at Boston University exposed some hidden variants that have languished in the shadow of

PAPER Mitter D, Pringsheim M, Kaulisch M, Plümacher KS, Schröder S, Warthemann R, Abou Jamra R, Baethmann M, Bast T, Büttel HM, Cohen JS, Conover E, Courage C, Eger A, Fatemi A, Grebe TA, Hauser NS, Heinritz W, Helbig KL, Heruth M, Huhle D, Höft K, Karch S, Kluger G, Korenke GC, Lemke JR, Lutz RE, Patzer S, Prehl I, Hoertnagel K, Ramsey K, Rating T, Rieß A, Rohena L, Schimmel M, Westman R, Zech FM, Zoll B, Malzahn D, Zirn B, Brockmann K

FOXG1 syndrome: genotype-phenotype association in 83 patients with FOXG1 variants.

Genet Med. 2018 Jan;20(1):98-108. Epub 2017 Jun 29 PubMed: 28661489

Vityala Yethindra

Warangal, India

PAPER Zulfiqar S, Garg P, Nieweg K

Contribution of astrocytes to metabolic dysfunction in the Alzheimer's disease brain.

Biol Chem. 2019 Aug 27;400(9):1113-1127. PubMed: 31188740

PAPER Jayaraj RL, Beiram R, Azimullah S, Meeran MF, Ojha SK, Adem A, Jalal FY

Lycopodium Attenuates Loss of Dopaminergic Neurons by Suppressing Oxidative Stress and Neuroinflammation in a Rat Model of Parkinson's Disease.

Molecules. 2019 Jun 10;24(11) PubMed: 31185705

PAPER Lerche S, Machetanz G, Wurster I, Roeben B, Zimmermann M, Pilotto A, Preische O, Stransky E, Deuschle C, Hauser AK, Schulte C, Lachmann I, Waniek K, Gasser T, Berg D, Maetzler W, Brockmann K

Dementia with lewy bodies: GBA1 mutations are associated with cerebrospinal fluid alpha-synuclein profile.

Mov Disord. 2019 Jul;34(7):1069-1073. Epub 2019 Jun 12 PubMed: 31189032

PAPER Sun Y, Kakinen A, Zhang C, Yang Y, Faridi A, Davis TP, Cao W, Ke PC, Ding F

Amphiphilic surface chemistry of fullerenols is necessary for inhibiting the amyloid aggregation of alpha-synuclein NACore.

Nanoscale. 2019 Jun 20;11(24):11933-11945. PubMed: 31188372

PAPER Ryan E, Seehra G, Sharma P, Sidransky E

GBA1-associated parkinsonism: new insights and therapeutic opportunities.

Curr Opin Neurol. 2019 Aug;32(4):589-596. PubMed: 31188151

PAPER Sampath C, Kalpana R, Ansah T, Charlton C, Hale A, Channon KM, Srinivasan S, Gangula PR

Impairment of Nrf2- and Nitrergic-Mediated Gastrointestinal Motility in an MPTP Mouse Model of Parkinson's Disease.

Dig Dis Sci. 2019 Dec;64(12):3502-3517. Epub 2019 Jun 11 PubMed: 31187328

PAPER Oh Y

Patient-specific pluripotent stem cell-based Parkinson's disease models showing endogenous alpha-synuclein aggregation.

BMB Rep. 2019 Jun;52(6):349-359. PubMed: 31186086