Alzheimer’s and Infectious Diseases Research Grants

GRANT Tuesday, June 11, 2019- 12:00 Infectious Diseases Society of America (IDSA) Foundation The IDSA Foundation is offering up to five one-time, $100,000 grants to researchers working to identify a microbial link to Alzheimer’s disease. The application period ...

Greg Czyryca

Allosterix Pharmaceuticals, LLC
Lehi, United States

Stefan Berghoff

Max Planck Institute of Experimental Medicine
Goettigen, Germany


MUTATIONS PSEN1 73659548 GRCh37 (105) rs1363575880 A C Exon 7 Point, Missense Coding Increased Aβ42 and Aβ42/Aβ40 ratio, with no effect on PSEN1 endoproteolysis or Aβ43 production, in transfected cells. In silico analyses yielded mixed results: SIFT=tolerated; ...


THERAPEUTICS AbbVie Alector Immunotherapy (active) Inflammation In March 2019, AL003 entered the clinic with a 52-person trial being run in Melbourne, Australia (May 2019 conference news). In a single-ascending-dose phase, 42 healthy participants receive infusions of ...


THERAPEUTICS AbbVie Alector Immunotherapy (active) Inflammation In November 2018, AL002 started INVOKE, a Phase 1 trial at six sites in the U.S., Australia, and the U.K. In its single-ascending-dose phase, 51 healthy adults receive infusions of one of nine escalating ...


MUTATIONS PSEN1 73659412 GRCh37 (105) 1384308168 G C Exon 7 Point, Missense Coding Unknown. In silico analyses predict it to be deleterious (SIFT, PolyPhen2, and Mutation Taster). Unknown W203C Amyotrophic Lateral Sclerosis: Unclear PathogenicityAmyotrophic Lateral ...

Eva Czirr on Two Proteins in Young Blood Give Synapses a SPARC

COMMENT It is exciting to read a paper focusing on potential mechanistic aspects of young plasma-mediated regeneration of the aging brain. In these elegantly designed studies, the focus lies on how synapse generation and synaptic function in human ES-cell-derived ...

Two Proteins in Young Blood Give Synapses a SPARC

RESEARCH NEWS 2019-06-11 Research News Human neurons sprouted more synapses and fired off more action potentials when bathed in serum from young, but not old, mice, according to a study published June 3 in Proceedings of the National Academy of Sciences. Kathlyn Gan and Thomas ...

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