PAPER Hauser RA, Olanow CW, Dzyngel B, Bilbault T, Shill H, Isaacson S, Dubow J, Agro A
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16420 RESULTS
PAPER Borkar N, Mu H, Holm R
Challenges and trends in apomorphine drug delivery systems for the treatment of Parkinson's disease.
Asian J Pharm Sci. 2018 Nov;13(6):507-517. Epub 2017 Dec 6 PubMed: 32104425PAPER Auffret M, Drapier S, Vérin M
The Many Faces of Apomorphine: Lessons from the Past and Challenges for the Future.
Drugs R D. 2018 Jun;18(2):91-107. PubMed: 29546602PAPER Bilbault T, Taylor S, Walker R, Grundy SL, Pappert EJ, Agro A
Buccal mucosal irritation studies of sublingual apomorphine film (APL-130277) in Syrian golden hamsters.
Ther Deliv. 2016 Sep;7(9):611-8. Epub 2016 Aug 10 PubMed: 27506115Kynmobi
THERAPEUTICS (9R)-10-methyl-10-azatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadeca-1(16),2(7),3,5,13(17),14-hexaene-3,4-diol Sunovion Pharmaceuticals Inc. APL-130277 apomorphine hydrochloride sublingual thin film Small Molecule Other Neurotransmitters Starting in August 2014, a
PSEN1 W294Ter
MUTATIONS PSEN1 73673106 GRCh37/hg19 G A Exon 9 Point, Nonsense Coding Unknown, but 3D in silico modeling predicted pronounced structural effects. Unknown, but MRI of two carriers showed white matter and subcortical lesions, and a third carrier had lesions in the o
Lucy Ruivo
Miami, United States
PAPER You C, Zeng W, Deng L, Lei Z, Gao X, Zhang VW, Wang Y
Identification and Clinical Analysis of the First Nonsense Mutation in the PSEN1 Gene in a Family With Acute Encephalopathy and Retinitis Pigmentosa.
Front Neurol. 2020;11:319. Epub 2020 May 5 PubMed: 32431660Daithi Cee
Ireland
Oren Levy
Regeneron PharmaceuticalsUnited States
Russell Swerdlow on Umbilical Cord With Presenilin Mutation Births New Cell Model of Familial AD
COMMENT This study extends prior cell culture, sub-cellular biochemical, animal, and human studies that show presenilin 1 mutations have biological consequences. As demonstrated nicely here, the stem-cell-derived model can facilitate studies of how specific PS1 m
PAPER Schweighauser M, Shi Y, Tarutani A, Kametani F, Murzin AG, Ghetti B, Matsubara T, Tomita T, Ando T, Hasegawa K, Murayama S, Yoshida M, Hasegawa M, Scheres SH, Goedert M
Structures of α-synuclein filaments from multiple system atrophy
bioXriv, February 6, 2020Umbilical Cord With Presenilin Mutation Births New Cell Model of Familial AD
RESEARCH NEWS 2020-05-28 Research News Induced pluripotent stem cell models of Alzheimer’s disease have become important because they allow researchers to study human neurons carrying AD mutations. However, iPSC lines take weeks to establish, require viral vectors to reprogram ad
Masaru Tanaka
Hungarian Academy of Sciences
PAPER Ren P, Chen J, Li B, Zhang M, Yang B, Guo X, Chen Z, Cheng H, Wang P, Wang S, Wang N, Zhang G, Wu X, Ma D, Guan D, Zhao R
Nrf2 Ablation Promotes Alzheimer's Disease-Like Pathology in APP/PS1 Transgenic Mice: The Role of Neuroinflammation and Oxidative Stress.
Oxid Med Cell Longev. 2020;2020:3050971. Epub 2020 May 11 PubMed: 32454936Current Filters
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