PAPER Chang S, Guo X, Li G, Zhang X, Li J, Jia Y, Nie K

Acupuncture promotes expression of Hsp84/86 and delays brain ageing in SAMP8 mice.

Acupunct Med. 2019 Dec;37(6):340-347. Epub 2019 Aug 15 PubMed: 31412703

PAPER Zhuang L, Yang Y, Gao J

Cognitive assessment tools for mild cognitive impairment screening.

J Neurol. 2019 Aug 14; PubMed: 31414193

PAPER Sung MS, Choi SM, Kim J, Ha JY, Kim BC, Heo H, Park SW

Inner retinal thinning as a biomarker for cognitive impairment in de novo Parkinson's disease.

Sci Rep. 2019 Aug 14;9(1):11832. PubMed: 31413302

PAPER Jiang AA, Longardner K, Dickson D, Sell R

Gerstmann-Sträussler-Scheinker syndrome misdiagnosed as conversion disorder.

BMJ Case Rep. 2019 Aug 13;12(8) PubMed: 31413052

PAPER Marín-Lahoz J, Sampedro F, Martinez-Horta S, Pagonabarraga J, Kulisevsky J

Depression as a Risk Factor for Impulse Control Disorders in Parkinson Disease.

Ann Neurol. 2019 Nov;86(5):762-769. Epub 2019 Aug 31 PubMed: 31415102

PAPER Miah J, Dawes P, Edwards S, Leroi I, Starling B, Parsons S

Patient and public involvement in dementia research in the European Union: a scoping review.

BMC Geriatr. 2019 Aug 14;19(1):220. PubMed: 31412788

PAPER Growcott EJ, Bamba D, Galarneau JR, Leonard VH, Schul W, Stein D, Osborne CS

The effect of P38 MAP kinase inhibition in a mouse model of influenza.

J Med Microbiol. 2018 Mar;67(3):452-462. Epub 2018 Jan 24 PubMed: 29458547

Yadong Huang on ApoE4 Glia Bungle Lipid Processing, Mess with the Matrisome

COMMENT This is an interesting and comprehensive whole-transcriptome study of APOE4 and Alzheimer’s disease (AD), using human iPSC-derived brain cells, mouse brain cells, and cell-type deconvoluted transcriptomic data from postmortem AD brains. An important findi

Sonal Agrawal

Rush University medical Center
Chicago, United States

Guojun Bu on ApoE4 Glia Bungle Lipid Processing, Mess with the Matrisome

COMMENT This is an exciting study demonstrating that APOE4 is associated with dysregulation of cholesterol homeostasis in human but not mouse astrocytes and microglia. Although such an association was implicated in previous studies, including those addressing APO

ApoE4 Glia Bungle Lipid Processing, Mess with the Matrisome

RESEARCH NEWS 2019-08-16 Research News ApoE4 predisposes people to Alzheimer’s disease by modulating astrocytes and microglia, suggest researchers led by Julia TCW and Alison Goate at the Icahn School of Medicine at Mount Sinai, New York. In a preprint on bioRχiv, the researchers

PAPER Fessler MB

The challenges and promise of targeting the Liver X Receptors for treatment of inflammatory disease.

Pharmacol Ther. 2018 Jan;181:1-12. Epub 2017 Jul 16 PubMed: 28720427

PAPER Camargo N, Goudriaan A, van Deijk AF, Otte WM, Brouwers JF, Lodder H, Gutmann DH, Nave KA, Dijkhuizen RM, Mansvelder HD, Chrast R, Smit AB, Verheijen MH

Oligodendroglial myelination requires astrocyte-derived lipids.

PLoS Biol. 2017 May;15(5):e1002605. Epub 2017 May 26 PubMed: 28549068

AppNL-G-F/MAPT double knock-in

RESEARCH MODELS Summary App NL-G-F /MAPT double knock-in mice represent a unique model for studying the nexus between human Aβ and human tau. These mice were created by crossing App NL-G-F mice with MAPT knock-in mice. In the former line, the endogenous mouse App gene wa

MAPT knock-in

RESEARCH MODELS Summary It has been suggested that differences in mouse and human tau may partially underlie the difficulty in modeling Alzheimer’s disease in mice (see Alzforum webinar). In this knock-in model, the entire genomic sequence of murine Mapt from exon 1 to e