PAPER Shang J, Yamashita T, Tian F, Li X, Liu X, Shi X, Nakano Y, Tsunoda K, Nomura E, Sasaki R, Tadokoro K, Sato K, Takemoto M, Hishikawa N, Ohta Y, Abe K
PAPER Mancuso R, Sicurella M, Agostini S, Marconi P, Clerici M31414935
PAPER McAlary L, Plotkin SS, Cashman NR31414322
PAPER Xu Y, Zhang Z, Jiang X, Chen X, Wang Z, Alsulami H, Qin HL, Tang W
Discovery of δ-sultone-fused pyrazoles for treating Alzheimer's disease: Design, synthesis, biological evaluation and SAR studies.Eur J Med Chem. 2019 Nov 1;181:111598. Epub 2019 Aug 6 PubMed: 31415981
PAPER Marín-Lahoz J, Sampedro F, Martinez-Horta S, Pagonabarraga J, Kulisevsky J31415102
PAPER Growcott EJ, Bamba D, Galarneau JR, Leonard VH, Schul W, Stein D, Osborne CS29458547
COMMENT This is an interesting and comprehensive whole-transcriptome study of APOE4 and Alzheimer’s disease (AD), using human iPSC-derived brain cells, mouse brain cells, and cell-type deconvoluted transcriptomic data from postmortem AD brains. An important ...
Rush University medical CenterChicago, United States
COMMENT This is an exciting study demonstrating that APOE4 is associated with dysregulation of cholesterol homeostasis in human but not mouse astrocytes and microglia. Although such an association was implicated in previous studies, including those addressing ...
RESEARCH NEWS 2019-08-16 Research News ApoE4 predisposes people to Alzheimer’s disease by modulating astrocytes and microglia, suggest researchers led by Julia TCW and Alison Goate at the Icahn School of Medicine at Mount Sinai, New York. In a preprint on bioRχiv, the researchers ...
PAPER Fessler MB
The challenges and promise of targeting the Liver X Receptors for treatment of inflammatory disease.Pharmacol Ther. 2018 Jan;181:1-12. Epub 2017 Jul 16 PubMed: 28720427
PAPER Camargo N, Goudriaan A, van Deijk AF, Otte WM, Brouwers JF, Lodder H, Gutmann DH, Nave KA, Dijkhuizen RM, Mansvelder HD, Chrast R, Smit AB, Verheijen MH28549068
RESEARCH MODELS Summary App NL-G-F /MAPT double knock-in mice represent a unique model for studying the nexus between human Aβ and human tau. These mice were created by crossing App NL-G-F mice with MAPT knock-in mice. In the former line, the endogenous mouse App gene ...
RESEARCH MODELS Summary It has been suggested that differences in mouse and human tau may partially underlie the difficulty in modeling Alzheimer’s disease in mice (see Alzforum webinar). In this knock-in model, the entire genomic sequence of murine Mapt from exon 1 to ...
Columbia UniversityNew York City, United States