Reserve & Resilience: 1st Workshop on Research Definitions for Reserve & Resilience in Cognitive Aging and Dementia
CONFERENCE 2019-09-09 00:00:00-2019-09-10 00:00:00 Bethesda, Maryland 09 – 10 September 2019 View Conference Website 1 ...
Laura Ranum on C9ORF72-ALS/FTD-associated poly(GR) binds Atp5a1 and compromises mitochondrial function in vivo.
COMMENT This work provides an additional mouse model and research tool for the C9 ALS/FTD community. Because C9 ALS/FTD disease is a complex disease, with the expression of two mutant transcripts (sense and antisense) and six dipeptide repeat-containing proteins, ...
Robert Baloh on C9ORF72-ALS/FTD-associated poly(GR) binds Atp5a1 and compromises mitochondrial function in vivo.
COMMENT This is a very nice addition to the building literature on mechanisms of toxicity from DPR expression in animal models. It brings to light a surprisingly specific mechanism, whereby poly(GR) alters mitochondrial ATP5A1, further linking mitochondrial ...
Adrian Isaacs on C9ORF72-ALS/FTD-associated poly(GR) binds Atp5a1 and compromises mitochondrial function in vivo.
COMMENT This paper describes an interesting new poly(GR)-expressing mouse model. We will need a range of different models to ultimately understand the role of each DPR and their contribution to C9ORF72-repeat pathology, so this is a welcome addition. The most ...
Ludo Van Den Bosch on C9ORF72-ALS/FTD-associated poly(GR) binds Atp5a1 and compromises mitochondrial function in vivo.
COMMENT This paper nicely shows that expression of a poly(GR) in all the layers of the cortex under the control of a CamKII promotor can induce an ALS/FTD-related phenotype. A major advantage of this study is that the poly(GR) is expressed at a relatively low ...
PAPER Rodriques SG, Stickels RR, Goeva A, Martin CA, Murray E, Vanderburg CR, Welch J, Chen LM, Chen F, Macosko EZ30923225
PAPER Kung WM, Ho YJ, Yoshizawa H, Matsuo S, Wei CY30534208
PAPER Liu S, Zhou Z, Zhang L, Meng S, Li S, Wang X
Inhibition of SIRT2 by Targeting GSK3β-Mediated Phosphorylation Alleviates SIRT2 Toxicity in SH-SY5Y Cells.Front Cell Neurosci. 2019;13:148. Epub 2019 Apr 24 PubMed: 31105527
PAPER Vasili E, Dominguez-Meijide A, Outeiro TF31105524
PAPER Grasso G, Rebella M, Morbiducci U, Tuszynski JA, Danani A, Deriu MA
The Role of Structural Polymorphism in Driving the Mechanical Performance of the Alzheimer's Beta Amyloid Fibrils.Front Bioeng Biotechnol. 2019;7:83. Epub 2019 Apr 24 PubMed: 31106199
PAPER Lin YT, Chou MC, Wu SJ, Yang YH31106076
PAPER Chen SJ, Tsai HH, Tsai LK, Tang SC, Lee BC, Liu HM, Yen RF, Jeng JS31105769
PAPER Melzer TR, Stark MR, Keenan RJ, Myall DJ, MacAskill MR, Pitcher TL, Livingston L, Grenfell S, Horne KL, Young BN, Pascoe MJ, Almuqbel MM, Wang J, Marsh SH, Miller DH, Dalrymple-Alford JC, Anderson TJ31105633