PAPER Jiang LL, Zhu B, Zhao Y, Li X, Liu T, Pina-Crespo J, Zhou L, Xu W, Rodriguez MJ, Yu H, Cleveland DW, Ravits J, Da Cruz S, Long T, Zhang D, Huang TY, Xu H

Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment.

J Clin Invest. 2019 May 21;129(8):3103-3120. PubMed: 31112137

PAPER Haaksma ML, Rizzuto D, Leoutsakos JS, Marengoni A, Tan EC, Olde Rikkert MG, Fratiglioni L, Melis RJ, Calderón-Larrañaga A

Predicting Cognitive and Functional Trajectories in People With Late-Onset Dementia: 2 Population-Based Studies.

J Am Med Dir Assoc. 2019 Nov;20(11):1444-1450. Epub 2019 May 17 PubMed: 31109912

PAPER Świetlik D, Białowąs J, Moryś J, Klejbor I, Kusiak A

Computer Modeling of Alzheimer's Disease-Simulations of Synaptic Plasticity and Memory in the CA3-CA1 Hippocampal Formation Microcircuit.

Molecules. 2019 May 17;24(10) PubMed: 31108977

Mariana Loredo

Monterrey , Mexico

Shabana Shaik

The University of Chicago
Chicago, United States

Judy Benjamin

Washington, United States

Anna Serga

Russian Federation

PAPER Lalonde R, Strazielle C

PS1 knockin mice with the Japanese I213T mutation: effects on exploratory activity, motor coordination, and spatial learning.

Behav Brain Res. 2005 Jul 30;162(2):182-90. PubMed: 15908021

American Academy of Neurology 2019 Annual Meeting

CONFERENCE COVERAGE SERIES Antisense Oligonucleotides: Can They Take on ALS, SMA, Prions? Drug Reported to Help Alzheimer’s Patients Sleep Better American Academy of Neurology 2019 Annual Meeting ...

Antisense Oligonucleotides: Can They Take on ALS, SMA, Prions?

CONFERENCE COVERAGE 2019-05-22 Conference Coverage At the American Academy of Neurology’s 71st Annual Meeting, held May 4–10 in Philadelphia, researchers showcased their latest data on antisense oligonucleotides (ASOs). These short, synthetic, single-stranded oligodeoxynucleotides bind ...

Alyce Tidball

C9ORF72 Toxicity Tied to Mitochondria, Transcriptional Machinery

RESEARCH NEWS 2019-05-22 Research News Two studies offer new potential ways of quelling the neuron-killing rampage of the C9ORF72 hexanucleotide expansion, the biggest genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). In one, a mouse model ...

Laura Blair

University of South Florida
Tampa, United States

PAPER Goodman LD, Prudencio M, Kramer NJ, Martinez-Ramirez LF, Srinivasan AR, Lan M, Parisi MJ, Zhu Y, Chew J, Cook CN, Berson A, Gitler AD, Petrucelli L, Bonini NM

Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD.

Nat Neurosci. 2019 Jun;22(6):863-874. Epub 2019 May 20 PubMed: 31110321

David Kowalski