PAPER Elgueta D, Contreras F, Prado C, Montoya A, Ugalde V, Chovar O, Villagra R, Henríquez C, Abellanas MA, Aymerich MS, Franco R, Pacheco R

Dopamine Receptor D3 Expression Is Altered in CD4+ T-Cells From Parkinson's Disease Patients and Its Pharmacologic Inhibition Attenuates the Motor Impairment in a Mouse Model.

Front Immunol. 2019;10:981. Epub 2019 May 1 PubMed: 31118938

PAPER Fisher EM, Bannerman DM

Mouse models of neurodegeneration: Know your question, know your mouse.

Sci Transl Med. 2019 May 22;11(493) PubMed: 31118292

PAPER Seritan AL, Rienas C, Duong T, Delucchi K, Ostrem JL

Ages at Onset of Anxiety and Depressive Disorders in Parkinson's Disease.

J Neuropsychiatry Clin Neurosci. 2019;31(4):346-352. Epub 2019 May 23 PubMed: 31117906

PAPER Yuan T, Chu C, Shi R, Cui T, Zhang X, Zhao Y, Shi X, Hui Y, Pan J, Qian R, Dai X, Liu Z, Liu X

ApoE-Dependent Protective Effects of Sesamol on High-Fat Diet-Induced Behavioral Disorders: Regulation of the Microbiome-Gut-Brain Axis.

J Agric Food Chem. 2019 Jun 5;67(22):6190-6201. Epub 2019 May 28 PubMed: 31117496

Brain Conference Spotlights Transcriptomics, Therapeutic Strategies

CONFERENCE COVERAGE 2019-05-24 Conference Coverage About 140 scientists gathered in Rungstedgaard, north of Copenhagen, Denmark, May 5–9 for the biannual Brain Conference organized by the Federation of European Neuroscience Societies and the Lundbeck Foundation. Co-chaired by Beth Stev

Neurogenesis Wanes in Alzheimer’s, Along With Cognition

RESEARCH NEWS 2019-05-24 Research News Does neurogenesis keep the brain sharp? This unsettled debate is getting new fuel this week. In the May 23 Cell Stem Cell online, researchers led by Orly Lazarov at the University of Illinois, Chicago, report that they can find newborn neuro

PAPER Bruel-Jungerman E, Veyrac A, Dufour F, Horwood J, Laroche S, Davis S

Inhibition of PI3K-Akt signaling blocks exercise-mediated enhancement of adult neurogenesis and synaptic plasticity in the dentate gyrus.

PLoS One. 2009 Nov 19;4(11):e7901. PubMed: 19936256

PAPER Chen MJ, Russo-Neustadt AA

Exercise activates the phosphatidylinositol 3-kinase pathway.

Brain Res Mol Brain Res. 2005 Apr 27;135(1-2):181-93. Epub 2005 Jan 26 PubMed: 15857681

PAPER Hu T, Zhou FJ, Chang YF, Li YS, Liu GC, Hong Y, Chen HL, Xiyang YB, Bao TH

miR21 is Associated with the Cognitive Improvement Following Voluntary Running Wheel Exercise in TBI Mice.

J Mol Neurosci. 2015 Sep;57(1):114-22. Epub 2015 May 28 PubMed: 26018937

PAPER Pons-Espinal M, Gasperini C, Marzi MJ, Braccia C, Armirotti A, Pötzsch A, Walker TL, Fabel K, Nicassio F, Kempermann G, De Pietri Tonelli D

MiR-135a-5p Is Critical for Exercise-Induced Adult Neurogenesis.

Stem Cell Reports. 2019 Jun 11;12(6):1298-1312. Epub 2019 May 23 PubMed: 31130358

PAPER Tobin MK, Musaraca K, Disouky A, Shetti A, Bheri A, Honer WG, Kim N, Dawe RJ, Bennett DA, Arfanakis K, Lazarov O

Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer's Disease Patients.

Cell Stem Cell. 2019 Jun 6;24(6):974-982.e3. Epub 2019 May 23 PubMed: 31130513

Anne-Sophie Hafner on Plasticity Hums With Protein Synthesis on Both Sides of Synapse

COMMENT I’d like to thank Celia Williams for bringing her paper to my attention. It is very interesting. I am not surprised she identified both dendritic and axonal genes. Synaptoneurosomes, as she beautifully shows in EM, have the particularity to be composed of

Anne-Sophie Hafner

Max-Planck-Institute for Brain Research
Frankfurt am Main, Germany

Valeria Battistella

Stroke Unit
Porto, Portugal

Jieming Chen

Zimbabwe