PAPER Li P, Marshall L, Oh G, Jakubowski JL, Groot D, He Y, Wang T, Petronis A, Labrie V
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PAPER Chiesa PA, Cavedo E, Vergallo A, Lista S, Potier MC, Habert MO, Dubois B, Thiebaut de Schotten M, Hampel H, INSIGHT-preAD study group, Alzheimer Precision Medicine Initiative (APMI)
Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer's disease.
Alzheimers Dement. 2019 Jul;15(7):940-950. Epub 2019 May 18 PubMed: 31113760PAPER Vergallo A, Mégret L, Lista S, Cavedo E, Zetterberg H, Blennow K, Vanmechelen E, De Vos A, Habert MO, Potier MC, Dubois B, Neri C, Hampel H, INSIGHT-preAD study group, Alzheimer Precision Medicine Initiative (APMI)
Plasma amyloid β 40/42 ratio predicts cerebral amyloidosis in cognitively normal individuals at risk for Alzheimer's disease.
Alzheimers Dement. 2019 Jun;15(6):764-775. Epub 2019 May 18 PubMed: 31113759PAPER Stephen TL, Cacciottolo M, Balu D, Morgan TE, LaDu MJ, Finch CE, Pike CJ
APOE genotype and sex affect microglial interactions with plaques in Alzheimer's disease mice.
Acta Neuropathol Commun. 2019 May 21;7(1):82. PubMed: 31113487PAPER Lin CH, Chen PK, Wang SH, Lane HY
Sodium benzoate for the treatment of behavioral and psychological symptoms of dementia (BPSD): A randomized, double-blind, placebo-controlled, 6-week trial.
J Psychopharmacol. 2019 Aug;33(8):1030-1033. Epub 2019 May 22 PubMed: 31113277PAPER Welcome MO
Gut Microbiota Disorder, Gut Epithelial and Blood-Brain Barrier Dysfunctions in Etiopathogenesis of Dementia: Molecular Mechanisms and Signaling Pathways.
Neuromolecular Med. 2019 Sep;21(3):205-226. Epub 2019 May 21 PubMed: 31115795Rick Young
, United States
Are Disease Mutations Lurking Within ‘Dark Regions’ of the Genome?
RESEARCH NEWS 2019-05-23 Research News It’s not just the dark web. The dark genome, too, hides some nefarious goings-on, and it will take creative sleuthing to drag them into the light. Genomic sequencing has had some success scanning for rare variants that cause disease. Still,
Katie Selzler
Eli LillyIndianapolis, United States
Jason Ulrich on When It Comes to Alzheimer’s Disease, Do Human Microglia Even Give a DAM?
COMMENT It is exciting to see all these studies examining cell-type-specific responses to Alzheimer’s disease pathology at the transcriptomic levels. The isolated cell-type approach from Srinivasan, Friedman et al. and the single-nucleus approach from Mathys, Dav
Elizabeth Bradshaw on Alzheimer's Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation.
COMMENT We have DAM, BAM, PAM, and now HAM (Human Alzheimer’s Microglia/Myeloid cells signature) to help us better understand how microglia change with disease. Srinivasan et al. used a novel method to isolate various cell types from frozen brain tissue, where th
When It Comes to Alzheimer’s Disease, Do Human Microglia Even Give a DAM?
RESEARCH NEWS 2019-05-23 Research News Myriad studies have placed microglia right in the middle of AD pathogenesis, but defining what, when, and how these cells influence the disease process in a person’s brain is difficult. Three recent gene-expression studies—one in Nature and
PAPER Del-Aguila JL, Li Z, Dube U, Mihindukulasuriya KA, Budde JP, Fernandez MV, Ibanez L, Bradley J, Wang F, Bergmann K, Davenport R, Morris JC, Holtzman DM, Perrin RJ, Benitez BA, Dougherty J, Cruchaga C, Harari O
A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain.
Alzheimers Res Ther. 2019 Aug 9;11(1):71. PubMed: 31399126PAPER Decalf J, Albert ML, Ziai J
New tools for pathology: a user's review of a highly multiplexed method for in situ analysis of protein and RNA expression in tissue.
J Pathol. 2019 Apr;247(5):650-661. Epub 2019 Feb 20 PubMed: 30570141PAPER Moffitt JR, Bambah-Mukku D, Eichhorn SW, Vaughn E, Shekhar K, Perez JD, Rubinstein ND, Hao J, Regev A, Dulac C, Zhuang X
Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region.
Science. 2018 Nov 16;362(6416) Epub 2018 Nov 1 PubMed: 30385464Current Filters
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