"Alzheimer's Afternoons" Seminar Series: MODEL-AD: Towards the Next Generation of Mouse Models for Alzheimer's Disease

CONFERENCE 2020-03-31 00:00:00-2020-03-31 00:00:00 Online Meeting 31 March 2020 Organizers: Lance Johnson, PhD, University of Kentucky and Rik van der Kant, PhD, Vrije Universiteit Amsterdam Speaker: Gareth Howell, PhD, The Jackson Laboratory Meeting time: 3:00- 4:00 PM EDT To join:  https://us04web.zoom.

PAPER Peterschmitt MJ, Gasser T, Isaacson S, Kulisevsky J, Mir P, Simuni T, Wills AM, Guedes LC, Svenningsson P P, Waters C, Ji AJ, Li J, Minini P, Nembo B, Saubadu S, Sharma J, Fischer T

Safety, tolerability and pharmacokinetics of oral venglustat in Parkinson disease patients with a GBA mutation

Science Direct February 2019

Debora Assum

Cordoba, Argentina

PAPER Cabrera-Salazar MA, Deriso M, Bercury SD, Li L, Lydon JT, Weber W, Pande N, Cromwell MA, Copeland D, Leonard J, Cheng SH, Scheule RK

Systemic delivery of a glucosylceramide synthase inhibitor reduces CNS substrates and increases lifespan in a mouse model of type 2 Gaucher disease.

PLoS One. 2012;7(8):e43310. Epub 2012 Aug 17 PubMed: 22912851

PAPER Sardi SP, Simuni T

New Era in disease modification in Parkinson's disease: Review of genetically targeted therapeutics.

Parkinsonism Relat Disord. 2019 Feb;59:32-38. Epub 2018 Oct 23 PubMed: 30391183

PAPER Schneider SA, Alcalay RN

Precision medicine in Parkinson's disease: emerging treatments for genetic Parkinson's disease.

J Neurol. 2020 Mar;267(3):860-869. Epub 2020 Jan 23 PubMed: 31974807

PAPER Yang M, Liu M, Ding Y, Vajda A, Ma J, Cui H, O'Brien T, Henshall D, Hardiman O, Shen S

Generation of twelve induced pluripotent stem cell lines from two healthy controls and two patients with sporadic amyotrophic lateral sclerosis.

Stem Cell Res. 2020 Apr;44:101752. Epub 2020 Mar 17 PubMed: 32208303

PAPER Binder JL, Chander P, Deretic V, Weick JP, Bhaskar K

Optical induction of autophagy via Transcription factor EB (TFEB) reduces pathological tau in neurons.

PLoS One. 2020;15(3):e0230026. Epub 2020 Mar 24 PubMed: 32208437

PAPER Marzban EN, Eldeib AM, Yassine IA, Kadah YM, Alzheimer’s Disease Neurodegenerative Initiative

Alzheimer's disease diagnosis from diffusion tensor images using convolutional neural networks.

PLoS One. 2020;15(3):e0230409. Epub 2020 Mar 24 PubMed: 32208428

PAPER Candasamy M, Mohamed Elhassan SA, Kumar Bhattamisra S, Hua WY, Sern LM, Binti Busthamin NA, Mohamad Ilni NB, Shun NS, Baohong L, Ya NS, Ying NW

Type 3 diabetes (Alzheimer's disease): new insight for promising therapeutic avenues.

Panminerva Med. 2020 Sep;62(3):155-163. Epub 2020 Mar 23 PubMed: 32208408

PAPER Park HJ, Cho S, Kim M, Jung YS

Carboxylic Acid-Functionalized, Graphitic Layer-Coated Three-Dimensional SERS Substrate for Label-Free Analysis of Alzheimer's Disease Biomarkers.

Nano Lett. 2020 Apr 8;20(4):2576-2584. Epub 2020 Mar 30 PubMed: 32207951

Venglustat

THERAPEUTICS Genzyme Sanofi Ibiglustat GZ/SAR402671 Genz-682452 Small Molecule alpha-synuclein Other Two Phase 1 safety, tolerability, and pharmacokinetics studies in 99 healthy volunteers were conducted in 2012 and 2013 under the drug name Genz-682452. Results are pu

Chaitra Sathyaprakash

University of Edinburgh
Edinburgh, United Kingdom

Sarah Dubroc

Alexandria, United States

PAPER Rodríguez-Chinchilla T, Quiroga-Varela A, Molinet-Dronda F, Belloso-Iguerategui A, Merino-Galan L, Jimenez-Urbieta H, Gago B, Rodriguez-Oroz MC

[18F]-DPA-714 PET as a specific in vivo marker of early microglial activation in a rat model of progressive dopaminergic degeneration.

Eur J Nucl Med Mol Imaging. 2020 Mar 23; PubMed: 32206840