Eli LillyIndianapolis, United States
COMMENT It is exciting to see all these studies examining cell-type-specific responses to Alzheimer’s disease pathology at the transcriptomic levels. The isolated cell-type approach from Srinivasan, Friedman et al. and the single-nucleus approach from Mathys, ...
Elizabeth Bradshaw on Alzheimer’s patient brain myeloid cells exhibit enhanced aging and unique transcriptional activation
COMMENT We have DAM, BAM, PAM, and now HAM (Human Alzheimer’s Microglia/Myeloid cells signature) to help us better understand how microglia change with disease. Srinivasan et al. used a novel method to isolate various cell types from frozen brain tissue, where ...
RESEARCH NEWS 2019-05-23 Research News Myriad studies have placed microglia right in the middle of AD pathogenesis, but defining what, when, and how these cells influence the disease process in a person’s brain is difficult. Three recent gene-expression studies—one in Nature and ...
PAPER Del-Aguila JL, Li Z, Dube U, Mihindukulasuriya KA, Budde JP, Fernandez MV, Ibanez L, Bradley J, Wang F, Bergmann K, Davenport R, Morris JC, Holtzman DM, Perrin RJ, Benitez BA, Dougherty J, Cruchaga C, Harari O
PAPER Decalf J, Albert ML, Ziai J
New tools for pathology: a user's review of a highly multiplexed method for in situ analysis of protein and RNA expression in tissue.J Pathol. 2019 Apr;247(5):650-661. Epub 2019 Feb 20 PubMed: 30570141
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PAPER Velmeshev D, Schirmer L, Jung D, Haeussler M, Perez Y, Mayer S, Bhaduri A, Goyal N, Rowitch DH, Kriegstein AR31097668
University of CambridgeCambridge, United Kingdom
PAPER Núñez P, Poza J, Gomez C, Rodríguez-González V, Hillebrand A, Tola-Arribas MÁ, Cano M, Hornero R
Characterizing the fluctuations of dynamic resting-state electrophysiological functional connectivity: Reduced neuronal coupling variability in mild cognitive impairment and dementia due to Alzheimer's disease.J Neural Eng. 2019 May 21; PubMed: 31112938
PAPER Benavente KS, Palmer RF, Royall DR31112230
PAPER Low A, Lim L, Lim L, Wong B, Silva E, Ng KP, Kandiah N
Construct validity of the Visual Cognitive Assessment Test (VCAT)-a cross-cultural language-neutral cognitive screening tool.Int Psychogeriatr. 2019 May 21;:1-9. PubMed: 31111797
PAPER Ding XL, Lei P31111428
PAPER Kim J, Ghadery C, Cho SS, Mihaescu A, Christopher L, Valli M, Houle S, Strafella AP31111400