Katie Selzler

Eli Lilly
Indianapolis, United States

Jason Ulrich on When it Comes to Alzheimer’s Disease, Do Human Microglia Even Give a DAM?

COMMENT It is exciting to see all these studies examining cell-type-specific responses to Alzheimer’s disease pathology at the transcriptomic levels. The isolated cell-type approach from Srinivasan, Friedman et al. and the single-nucleus approach from Mathys, ...

Elizabeth Bradshaw on Alzheimer’s patient brain myeloid cells exhibit enhanced aging and unique transcriptional activation

COMMENT We have DAM, BAM, PAM, and now HAM (Human Alzheimer’s Microglia/Myeloid cells signature) to help us better understand how microglia change with disease. Srinivasan et al. used a novel method to isolate various cell types from frozen brain tissue, where ...

When it Comes to Alzheimer’s Disease, Do Human Microglia Even Give a DAM?

RESEARCH NEWS 2019-05-23 Research News Myriad studies have placed microglia right in the middle of AD pathogenesis, but defining what, when, and how these cells influence the disease process in a person’s brain is difficult. Three recent gene-expression studies—one in Nature and ...

PAPER Del-Aguila JL, Li Z, Dube U, Mihindukulasuriya KA, Budde JP, Fernandez MV, Ibanez L, Bradley J, Wang F, Bergmann K, Davenport R, Morris JC, Holtzman DM, Perrin RJ, Benitez BA, Dougherty J, Cruchaga C, Harari O

A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain.

Alzheimers Res Ther. 2019 Aug 9;11(1):71. PubMed: 31399126

PAPER Decalf J, Albert ML, Ziai J

New tools for pathology: a user's review of a highly multiplexed method for in situ analysis of protein and RNA expression in tissue.

J Pathol. 2019 Apr;247(5):650-661. Epub 2019 Feb 20 PubMed: 30570141

PAPER Moffitt JR, Bambah-Mukku D, Eichhorn SW, Vaughn E, Shekhar K, Perez JD, Rubinstein ND, Hao J, Regev A, Dulac C, Zhuang X

Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region.

Science. 2018 Nov 16;362(6416) Epub 2018 Nov 1 PubMed: 30385464

PAPER Velmeshev D, Schirmer L, Jung D, Haeussler M, Perez Y, Mayer S, Bhaduri A, Goyal N, Rowitch DH, Kriegstein AR

Single-cell genomics identifies cell type-specific molecular changes in autism.

Science. 2019 May 17;364(6441):685-689. PubMed: 31097668

Priya Gami-Patel

Verena Zyka

University of Cambridge
Cambridge, United Kingdom

PAPER Benavente KS, Palmer RF, Royall DR

Serum Adiponectin is Related to Dementia.

J Gerontol A Biol Sci Med Sci. 2019 Apr 25; PubMed: 31112230

PAPER Low A, Lim L, Lim L, Wong B, Silva E, Ng KP, Kandiah N

Construct validity of the Visual Cognitive Assessment Test (VCAT)-a cross-cultural language-neutral cognitive screening tool.

Int Psychogeriatr. 2019 May 21;:1-9. PubMed: 31111797

PAPER Ding XL, Lei P

Plasma Replacement Therapy for Alzheimer's Disease.

Neurosci Bull. 2019 May 20; PubMed: 31111428

PAPER D'Arrigo JS

Targeting Early Dementia: Using Lipid Cubic Phase Nanocarriers to Cross the Blood⁻Brain Barrier.

Biomimetics (Basel). 2018 Mar 7;3(1) PubMed: 31105226

PAPER Mastwyk M, Barac AM, Radler M, Sgambellone R, Pather Lowen V, Mitchell N, Zisis G, Cleon Rowe C, Louis Masters C

Science media-the best way to reach the target audience for a pre-clinical AD study.

Int Psychogeriatr. 2019 May 21;:1-2. PubMed: 31111805