PAPER Esfandiarei M, Hoxha B, Talley NA, Anderson MR, Alkhouli MF, Squire MA, Eckman DM, Babu JR, Lopaschuk GD, Broderick TL
PAPER Chiesa PA, Cavedo E, Vergallo A, Lista S, Potier MC, Habert MO, Dubois B, Thiebaut de Schotten M, Hampel H, INSIGHT-preAD study group, Alzheimer Precision Medicine Initiative (APMI)
Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer's disease.Alzheimers Dement. 2019 Jul;15(7):940-950. Epub 2019 May 18 PubMed: 31113760
PAPER Vergallo A, Mégret L, Lista S, Cavedo E, Zetterberg H, Blennow K, Vanmechelen E, De Vos A, Habert MO, Potier MC, Dubois B, Neri C, Hampel H, INSIGHT-preAD study group, Alzheimer Precision Medicine Initiative (APMI)
Plasma amyloid β 40/42 ratio predicts cerebral amyloidosis in cognitively normal individuals at risk for Alzheimer's disease.Alzheimers Dement. 2019 Jun;15(6):764-775. Epub 2019 May 18 PubMed: 31113759
PAPER Stephen TL, Cacciottolo M, Balu D, Morgan TE, LaDu MJ, Finch CE, Pike CJ31113487
PAPER Lin CH, Chen PK, Wang SH, Lane HY
Sodium benzoate for the treatment of behavioral and psychological symptoms of dementia (BPSD): A randomized, double-blind, placebo-controlled, 6-week trial.J Psychopharmacol. 2019 Aug;33(8):1030-1033. Epub 2019 May 22 PubMed: 31113277
PAPER De Riva V, Galloni E, Lealini B, Zarantonello G, Disco C, Dionisio LD, Meligrana L, Marcon M, Perini F31115229
, United States
RESEARCH NEWS 2019-05-23 Research News It’s not just the dark web. The dark genome, too, hides some nefarious goings-on, and it will take creative sleuthing to drag them into the light. Genomic sequencing has had some success scanning for rare variants that cause disease. Still, ...
Eli LillyIndianapolis, United States
COMMENT It is exciting to see all these studies examining cell-type-specific responses to Alzheimer’s disease pathology at the transcriptomic levels. The isolated cell-type approach from Srinivasan, Friedman et al. and the single-nucleus approach from Mathys, ...
Elizabeth Bradshaw on Alzheimer’s patient brain myeloid cells exhibit enhanced aging and unique transcriptional activation
COMMENT We have DAM, BAM, PAM, and now HAM (Human Alzheimer’s Microglia/Myeloid cells signature) to help us better understand how microglia change with disease. Srinivasan et al. used a novel method to isolate various cell types from frozen brain tissue, where ...
RESEARCH NEWS 2019-05-23 Research News Myriad studies have placed microglia right in the middle of AD pathogenesis, but defining what, when, and how these cells influence the disease process in a person’s brain is difficult. Three recent gene-expression studies—one in Nature and ...
PAPER Del-Aguila JL, Li Z, Dube U, Mihindukulasuriya KA, Budde JP, Fernandez MV, Ibanez L, Bradley J, Wang F, Bergmann K, Davenport R, Morris JC, Holtzman DM, Perrin RJ, Benitez BA, Dougherty J, Cruchaga C, Harari O31399126
PAPER Decalf J, Albert ML, Ziai J
New tools for pathology: a user's review of a highly multiplexed method for in situ analysis of protein and RNA expression in tissue.J Pathol. 2019 Apr;247(5):650-661. Epub 2019 Feb 20 PubMed: 30570141
PAPER Moffitt JR, Bambah-Mukku D, Eichhorn SW, Vaughn E, Shekhar K, Perez JD, Rubinstein ND, Hao J, Regev A, Dulac C, Zhuang X30385464