The European Conference on Controversies in Huntington's Disease

CONFERENCE 2020-02-13 00:00:00-2020-02-14 00:00:00 Vienna, Austria 13 February 2020 to 14 February 2020 View Conference Website 1

PAPER Cai T, Hatano A, Kanatsu K, Tomita T

Histidine 131 in presenilin 1 is the pH-sensitive residue that causes the increase in Aβ42 level in acidic pH.

J Biochem. 2020 May 1;167(5):463-471. PubMed: 31816046

Corey McMillan

University of Pennsylvania
Philadelphia, United States

Richard Moon

Idorsia Pharmaceuticals
Allschwil, Switzerland

Rosie Mitchell

Manchester Metropolitan University
Manchester , United Kingdom

Arne Ittner on Tau deletion reduces plaque-associated BACE1 accumulation and decelerates plaque formation in a mouse model of Alzheimer's disease.

COMMENT BACE inhibition as therapeutic strategy has experienced significant setbacks due to nonspecific inhibition of BACE2 as well as inhibition of tissue BACE1, both of which have resulted in significant adverse effects in human clinical trials. New hope to ref

Arne Ittner

Macquarie University
Sydney, Australia

Anakha Ajayan

University of Southern California
Los Angeles , United States

Terrence Town, Anakha Ajayan on Does a Breached Blood-Brain Barrier Cause Seizures in AD?

COMMENT This interesting study draws an important causal link between dysregulated innate immune signaling due to blood-brain-barrier breakdown and neural dysfunction in aging, which has important implications for age-related neurodegenerative diseases including

PAPER Salama RM, Abdel-Latif GA, Abbas SS, El Magdoub HM, Schaalan MF

Neuroprotective effect of crocin against rotenone-induced Parkinson's disease in rats: Interplay between PI3K/Akt/mTOR signaling pathway and enhanced expression of miRNA-7 and miRNA-221.

Neuropharmacology. 2020 Mar 1;164:107900. Epub 2019 Dec 5 PubMed: 31811872

PAPER Singh S, DeMarco ML

In Vitro Conversion Assays Diagnostic for Neurodegenerative Proteinopathies.

J Appl Lab Med. 2020 Jan 1;5(1):142-157. PubMed: 31811072

PAPER Prior DE, Stommel E, Lawson VH, Kandel J, Robbins NM

Distribution of serum creatine kinase levels in amyotrophic lateral sclerosis.

Muscle Nerve. 2019 Dec 6; PubMed: 31811651

PAPER Casci I, Krishnamurthy K, Kour S, Tripathy V, Ramesh N, Anderson EN, Marrone L, Grant RA, Oliver S, Gochenaur L, Patel K, Sterneckert J, Gleixner AM, Donnelly CJ, Ruepp MD, Sini AM, Zuccaro E, Pennuto M, Pasinelli P, Pandey UB

Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization.

Nat Commun. 2019 Dec 6;10(1):5583. PubMed: 31811140

PAPER Porte B, Marguerit G, Thomasseau S, Paquet C, Hugon J

Dose-dependent neuroprotective effect of the JNK inhibitor Brimapitide in 5xFAD transgenic mice.

Brain Res. 2020 Jan 15;1727:146587. Epub 2019 Dec 4 PubMed: 31811838

PAPER Sidibé H, Vande Velde C

RNA Granules and Their Role in Neurodegenerative Diseases.

Adv Exp Med Biol. 2019;1203:195-245. PubMed: 31811636