PAPER Höglund K, Kern S, Zettergren A, Börjesson-Hansson A, Zetterberg H, Skoog I, Blennow K

Publisher Correction: Preclinical amyloid pathology biomarker positivity: effects on tau pathology and neurodegeneration.

Transl Psychiatry. 2018 Nov 19;8(1):250. PubMed: 30455463

PAPER Rosenberg RN, Fu M, Lambracht-Washington D

Active full-length DNA Aβ42 immunization in 3xTg-AD mice reduces not only amyloid deposition but also tau pathology.

Alzheimers Res Ther. 2018 Nov 20;10(1):115. PubMed: 30454039

PAPER Karthick C, Nithiyanandan S, Essa MM, Guillemin GJ, Jayachandran SK, Anusuyadevi M

Time-dependent effect of oligomeric amyloid-β (1-42)-induced hippocampal neurodegeneration in rat model of Alzheimer's disease.

Neurol Res. 2019 Feb;41(2):139-150. Epub 2018 Nov 19 PubMed: 30453864

PAPER Shetty A, Camicioli R, Ba F

Progressive Supranuclear Palsy-like Syndrome from Possible Cerebral Amyloid Angiopathy.

Can J Neurol Sci. 2019 Jan;46(1):132-136. Epub 2018 Nov 20 PubMed: 30457071

PAPER Viguier A, Girardie P, Raposo N, Calviere L, Denuelle M, Valton L, Olivot JM, Albucher JF, Bonneville F, Curot J

Teaching Video NeuroImages: Cerebral amyloid angiopathy-related transient focal neurologic episodes: A video-EEG report.

Neurology. 2018 Nov 20;91(21):e2033-e2034. PubMed: 30455265

Tamara Kirshbaum

Cayman Islands

Could Rogue APP Variants Invade Genome of Individual Neurons?

RESEARCH NEWS 2018-11-21 Research News Multiple copies of the amyloid precursor gene crop up in adult neurons of the human brain, creating a heterogeneous neuronal landscape in a single person. This is especially true in brains from people with sporadic Alzheimer’s disease, but h

Nisha Kuzhuppilly Ramakrishnan

University of Cambridge
United Kingdom

Michael Rafii on Could Rogue APP Variants Invade Genome of Individual Neurons?

COMMENT In a very thoughtful and well-designed set of experiments, Jerold Chun’s team further advances our knowledge of neuronal mosaicism and its possible relevance to brain function and disease. DNA replication must be extremely well-controlled and precise in o

Christos Proukakis on Could Rogue APP Variants Invade Genome of Individual Neurons?

COMMENT In this truly remarkable ground-breaking study, the Jerold Chun group conclusively demonstrate a totally unexpected cause of genomic variability in the human brain: the incorporation of abnormal forms of the APP gene apparently reverse-transcribed from mR

PAPER Lee MH, Siddoway B, Kaeser GE, Segota I, Rivera R, Romanow WJ, Liu CS, Park C, Kennedy G, Long T, Chun J

Somatic APP gene recombination in Alzheimer's disease and normal neurons.

Nature. 2018 Nov;563(7733):639-645. Epub 2018 Nov 21 PubMed: 30464338

PAPER Poduri A, Evrony GD, Cai X, Walsh CA

Somatic mutation, genomic variation, and neurological disease.

Science. 2013 Jul 5;341(6141):1237758. PubMed: 23828942

Kim Raucci

United States

Daksha Bhat

India

PAPER Konttinen H, Gureviciene I, Oksanen M, Grubman A, Loppi S, Huuskonen MT, Korhonen P, Lampinen R, Keuters M, Belaya I, Tanila H, Kanninen KM, Goldsteins G, Landreth G, Koistinaho J, Malm T

PPARβ/δ-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1ΔE9 astrocytes.

Glia. 2019 Jan;67(1):146-159. Epub 2018 Nov 19 PubMed: 30453390