PAPER von Essen MR, Hellem MN, Vinther-Jensen T, Ammitzbøll C, Hansen RH, Hjermind LE, Nielsen TT, Nielsen JE, Sellebjerg F
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PAPER Chitre NM, Moniri NH, Murnane KS
Omega-3 Fatty Acids as Druggable Therapeutics for Neurodegenerative Disorders.
CNS Neurol Disord Drug Targets. 2019;18(10):735-749. PubMed: 31724519Scientists Discover a Common Distress Signal in the Blood-Brain Barrier
RESEARCH NEWS 2019-11-15 Research News Whether in the wake of a stroke, seizure, massive neuroinflammation, or a blow to the head, the endothelial cells of the blood-brain barrier respond with remarkable similarity, according to a study published in the November issue of Nature N
Giuseppe Faraco on Scientists Discover a Common Distress Signal in the Blood-Brain Barrier
COMMENT This is an interesting study providing useful data for the understanding of brain endothelial function in both physiological and pathological conditions. The study shows that in different models of neurodegenerative diseases, the transcriptional responses
Tony Wyss-Coray on Scientists Discover a Common Distress Signal in the Blood-Brain Barrier
COMMENT This exciting study provides a comprehensive data resource on the molecular underpinnings of brain endothelial cell dysfunction. It builds on the group's prior work providing a healthy blood-brain barrier (BBB) transcriptome, an already incredibly us
Axel Montagne on Scientists Discover a Common Distress Signal in the Blood-Brain Barrier
COMMENT This is a noteworthy study by the Daneman lab comparing the transcriptional profiles of mouse blood-brain barrier (BBB) endothelial cells (ECs) with those in other organs of the body (i.e., heart, lung, kidney, and liver) using RNA-Seq method and an induc
David Attwell on Scientists Discover a Common Distress Signal in the Blood-Brain Barrier
COMMENT This is an exciting paper from the Daneman group that studies how the unique characteristics of endothelial cells (ECs) around brain capillaries change in different types of pathology, in such a way that the ECs start to resemble ECs on peripheral capilla
PAPER Munji RN, Soung AL, Weiner GA, Sohet F, Semple BD, Trivedi A, Gimlin K, Kotoda M, Korai M, Aydin S, Batugal A, Cabangcala AC, Schupp PG, Oldham MC, Hashimoto T, Noble-Haeusslein LJ, Daneman R
Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood-brain barrier dysfunction module.
Nat Neurosci. 2019 Oct 14; PubMed: 31611708Dipeptide Repeat Proteins Don’t Directly Block Nuclear Transport
RESEARCH NEWS 2019-11-15 Research News Lots of evidence suggests dipeptide repeat proteins translated from hexanucleotide repeat expansions in C9ORF72 interfere with transport of proteins in and out of the cell’s nucleus. However, an October 31 paper in Scientific Reports suggest
Lei Feng on China Approves Seaweed Sugar as First New Alzheimer’s Drug in 17 Years
COMMENT The authors should publish the full study as soon as possible. The observed effect size is relatively small, and is only slightly greater than the minimal clinically important difference of ADAS Cog. So, I don't view this as a breakthrough. If they s
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PAPER Bernis ME, Tamgüney G
Bioluminescence Imaging of Neuroinflammation in a Mouse Model of Parkinson's Disease.
Methods Mol Biol. 2020;2081:147-159. PubMed: 31721123PAPER Chen C, Lv Y, Hu C, Xu XF, Zhang RQ, Xiao K, Ma Y, Gao LP, Li JL, Shi Q, Wang J, Shi Q, Dong XP
Alternative complement pathway is activated in the brains of scrapie-infected rodents.
Med Microbiol Immunol. 2020 Feb;209(1):81-94. Epub 2019 Nov 12 PubMed: 31720785PAPER Dal Prà I, Armato U, Chiarini A
Family C G-Protein-Coupled Receptors in Alzheimer's Disease and Therapeutic Implications.
Front Pharmacol. 2019;10:1282. Epub 2019 Oct 28 PubMed: 31719824Current Filters
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