PAPER Ljubenkov PA, Miller Z, Mumford P, Zhang J, Allen IE, Mitic L, Staffaroni A, Heuer H, Rojas JC, Cobigo Y, Karydas A, Pearlman R, Miller B, Kramer JH, McGrath MS, Rosen HJ, Boxer AL
SEARCH RESULTS
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PAPER Webster JM, Darling AL, Uversky VN, Blair LJ
Small Heat Shock Proteins, Big Impact on Protein Aggregation in Neurodegenerative Disease.
Front Pharmacol. 2019;10:1047. Epub 2019 Sep 18 PubMed: 31619995PAPER O'Hara D, Davis GM, Adlesic NA, Hayes JM, Davey GP
Dichloroacetate Stabilizes Mitochondrial Fusion Dynamics in Models of Neurodegeneration.
Front Mol Neurosci. 2019;12:219. Epub 2019 Sep 18 PubMed: 31619961PAPER Matsura T
Protective Effect of Tocotrienol on In Vitro and In Vivo Models of Parkinson's Disease.
J Nutr Sci Vitaminol (Tokyo). 2019;65(Supplement):S51-S53. PubMed: 31619646PAPER Agus F, Crespo D, Myers RH, Labadorf A
The caudate nucleus undergoes dramatic and unique transcriptional changes in human prodromal Huntington's disease brain.
BMC Med Genomics. 2019 Oct 16;12(1):137. PubMed: 31619230PAPER Leta V, Jenner P, Chaudhuri KR, Antonini A
Can therapeutic strategies prevent and manage dyskinesia in Parkinson's disease? An update.
Expert Opin Drug Saf. 2019 Dec;18(12):1203-1218. Epub 2019 Nov 5 PubMed: 31619083David Jones on Imaging Model Locates Epicenter of Disease, Predicts Atrophy
COMMENT I find the work by Brown et al. to be important and interesting in that they provide a novel framework for single-subject outcome measures based on network physiology. This provides more evidence that the key biology at play in neurodegenerative diseases
Rik Ossenkoppele on Imaging Model Locates Epicenter of Disease, Predicts Atrophy
COMMENT This is very elegant work from Jesse Brown and colleagues. I found two aspects of the study particularly noteworthy. The first is the idea of a personalized prediction model of longitudinal brain atrophy based on the trans-neuronal spreading hypothesis. T
Imaging Model Locates Epicenter of Disease, Predicts Atrophy
RESEARCH NEWS 2019-10-18 Research News In neurodegenerative diseases, specific brain regions take the brunt of pathology and atrophy. However, differences from one patient to another make it hard to predict the precise path of progression for any one person. Now, scientists led b
PAPER Brown JA, Deng J, Neuhaus J, Sible IJ, Sias AC, Lee SE, Kornak J, Marx GA, Karydas AM, Spina S, Grinberg LT, Coppola G, Geschwind DH, Kramer JH, Gorno-Tempini ML, Miller BL, Rosen HJ, Seeley WW
Patient-Tailored, Connectivity-Based Forecasts of Spreading Brain Atrophy.
Neuron. 2019 Dec 4;104(5):856-868.e5. Epub 2019 Oct 14 PubMed: 31623919Susanne Krasemann on In Tauopathy, ApoE Destroys Neurons Via Microglia
COMMENT Dissecting the contribution of p-tau itself versus the innate immune system to neuronal loss in a model of tau pathology, this new study from the lab of David Holtzman showed that neuronal pathology and loss is almost exclusively driven by microglia. More
Could Getting Enough REST Extend Your Life?
RESEARCH NEWS 2019-10-18 Research News Why do some people age better than others? In the October 16 Nature, researchers led by Bruce Yankner at Harvard Medical School once again credit the repressor element 1-silencing transcription factor (REST). People who lived to a ripe old a
Li-Huei Tsai on Could Getting Enough REST Extend Your Life?
COMMENT The need to understand drivers of healthy aging is critically important for today’s society, one that invests heavily in promoting longevity but continues to be burdened by age-associated impairments. In their recent paper, Zullo, Drake, and colleagues sh
Jazmin Florio
UC San DiegoLa Jolla, United States
PAPER Tavernarakis N
Neural excitation moderates lifespan
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