COMMENT Both the Holtzman lab and our lab explored the role of microglia in mediating tau-induced neurodegenerative phenotypes in mice. Here, Shi et al. present exciting results of marked neuroprotection in a tau model after microglial ablation. In a different ta

Tau Natively Unstructured? Not Always, New Study Says

RESEARCH NEWS 2019-10-17 Research News Researchers for years thought that tau was a natively unstructured protein. Then how in the world do its supposedly disordered monomers give rise to the orderly stacks of tau molecules seen in tau fibrils? Using chemical cross-linkers to fre

PAPER Popov KI, Makepeace KA, Petrotchenko EV, Dokholyan NV, Borchers CH

Insight into the Structure of the "Unstructured" Tau Protein.

Structure. 2019 Nov 5;27(11):1710-1715.e4. Epub 2019 Oct 15 PubMed: 31628033

PAPER Brodie NI, Popov KI, Petrotchenko EV, Dokholyan NV, Borchers CH

Solving protein structures using short-distance cross-linking constraints as a guide for discrete molecular dynamics simulations.

Sci Adv. 2017 Jul;3(7):e1700479. Epub 2017 Jul 7 PubMed: 28695211

In Tauopathy, ApoE Destroys Neurons Via Microglia

RESEARCH NEWS 2019-10-17 Research News ApoE4 delivers a blow to neurons in mouse models of tauopathy but, according to a paper published October 10 in the Journal of Experimental Medicine, it only does so if mice have their microglia. Researchers led by David Holtzman at Washingt

TAK-341

THERAPEUTICS AstraZeneca Takeda Pharmaceutical Company MEDI1341 Immunotherapy (passive) alpha-synuclein In October 2017, Astra Zeneca began a Phase 1 single-ascending-dose study in 48 healthy volunteers age 18 to 65. Each volunteer was to receive a one-hour intravenou

Priscila Sanchez

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Lespedeza bicolor Extract Improves Amyloid Beta25 - 35-Induced Memory Impairments by Upregulating BDNF and Activating Akt, ERK, and CREB Signaling in Mice.

Apathy as a behavioural marker of cognitive impairment in Parkinson's disease: a longitudinal analysis.

Effects of Cognitive Performance and Affective Status on Fatigue in Parkinson's Disease.

Using MRI to Identify Supranuclear Palsy from Parkinson Disease and Dementia with Lewy Bodies.

Screening for Adverse Drug Reactions in Dementia Patients on Cholinesterase Inhibitor Therapy.

Using induced pluripotent stem cells for modeling Parkinson's disease.

Chromosome Instability in the Neurodegenerating Brain.

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Rachel Bennett, Bradley Hyman on In Tauopathy, ApoE Destroys Neurons Via Microglia