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University of CalgaryCalgary, Canada
COMMENT We appreciate Dr. Kukull’s thoughtful comments. He identifies the importance of randomization to establish comparability of treatment groups in clinical trials. We have no evidence that the treatment groups in this RCT differed with respect to any ...
COMMENT I appreciate the interesting points in two separate comments by Drs. Tanaka and Ozdinler. The published work of Tanaka’s group on the role of mutant PFN1 disorganizing TDP-43 is of great interest and is consistent with the evidence that we presented that ...
COMMENT We are grateful for Dr. Hendrie’s kind words and reasonable caution. We agree that engagement in cognitive, physical, and/or social activities needs to be a lifetime process. We inculcated that message by having participants develop activity goals that ...
Thomas Jefferson UniversityPhiladelphia, United States
RESEARCH MODELS Summary This mouse model of ALS expresses wild-type human TDP-43 in postnatal neurons. Mice homozygous for the human TARDP transgene are referred to as TAR6/6, while mice hemizygous for the transgene are called TAR6. This description refers to homozygous, ...