16043 RESULTS
COMMENT I met Rahul Desikan when we were both invited to attend the third annual Charleston Conference on Alzheimer's Disease in 2015 as Early Career Investigators. Literally within the first day of meeting, Rahul began running analyses to help me address re
COMMENT This is impressive work providing exciting new tools (a large library of isogenic APP and PS1 mutant iPSCs) to explore AD pathogenesis. They describe that both APP and PS1 mutant iPSCs have remarkably overlapping alterations in gene and protein expression
Pasadena, United States
COMMENT The authors did a tremendous job in creating a broad resource. Isogenic FAD/control iPSCs will likely set a new standard in the cellular modelling of AD-related phenotypes, and the lines reported here hopefully will be readily made available to a broader
United States
UFPelPelotas, Brazil
University of Wisconsin-MadisonMadison, United States
CONFERENCE 2020-01-18 00:00:00-2020-01-19 00:00:00 Miami, Florida 18 January 2020 to 19 January 2020 View Conference Website 0
The Rockefeller UniversityNew York, United States
VaccinexRochester, United States
Vaccinex, Inc.Rochester, United States
COMMENT The overexpression paradigm is less problematic for modeling tauopathy than for Aβ amyloidosis because limited proteolysis is not a prerequisite for physiological and pathological processing of tau protein. Overexpression of APP results in overproduction
COMMENT We appreciate the new comment from Dr. Kipnis and colleagues and their willingness to engage in discussion on this controversial topic. We also feel the need to clarify some of the statements that have been made by these authors in their comments to this
PAPER Mastorakos P, McGavern D
PAPER Killer HE
