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PAPER Dhekne HS, Yanatori I, Gomez RC, Tonelli F, Diez F, Schüle B, Steger M, Alessi DR, Pfeffer SR
A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain.
Elife. 2018 Nov 6;7 PubMed: 30398148PAPER Wallings R, McFarland K, Staley H, Neighbarger N, Schaake S, Brueggemann N, Zittel S, Usnich T, Klein C, Sammler E, Tansey MG
The R1441C-LRRK2 mutation induces myeloid immune cell exhaustion in an age- and sex-dependent manner
bioRxiv2023.10.12.562063Emanuele Buratti on ‛iNET’ Cultures Expose NPTX2 as TDP-43 Henchman
COMMENT One great drawback when studying proteins like TDP-43 is the incredible number of genes whose expression is controlled by this protein, and which become misregulated following TDP-43 aggregation in pathological conditions. From a therapeutic point of view
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‛iNET’ Cultures Expose NPTX2 as TDP-43 Henchman
RESEARCH NEWS 2024-02-23 Research News The pathological accumulation of TDP-43 that underlies many cases of FTD, ALS, and LATE-NC has been notoriously difficult to recapitulate in mice or cultured human cells. In a paper published February 14 in Nature, scientists led by Magdalin
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PAPER Ding Y, Luan W, Shen X, Wang Z, Cao Y
E2F1 Mediates Traumatic Brain Injury and Regulates BDNF-AS to Promote the Progression of Alzheimer's Disease.
Neurotox Res. 2024 Feb 22;42(2):17. PubMed: 38386202PAPER Mao S, Huang X, Chen R, Zhang C, Diao Y, Li Z, Wang Q, Tang S, Guo S
STW-MD: a novel spatio-temporal weighting and multi-step decision tree method for considering spatial heterogeneity in brain gene expression data.
Brief Bioinform. 2024 Jan 22;25(2) PubMed: 38385881PAPER Malar DS, Verma K, Prasanth MI, Tencomnao T, Brimson JM
Network analysis-guided drug repurposing strategies targeting LPAR receptor in the interplay of COVID, Alzheimer's, and diabetes.
Sci Rep. 2024 Feb 21;14(1):4328. PubMed: 38383841PAPER Gaggi NL, Collins KA, Gonzalez-Castillo J, Hurtado AM, Castellanos FX, Osorio R, Cassano P, Iosifescu DV
Transcranial photobiomodulation increases intrinsic brain activity within irradiated areas in early Alzheimer's disease: Potential link with cerebral metabolism.
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Freestanding Nanofiber-Assembled Aptasensor for Precisely and Ultrafast Electrochemical Detection of Alzheimer's Disease Biomarkers.
Adv Healthc Mater. 2024 Feb 22;:e2304355. PubMed: 38387159Current Filters
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