Fog Beginning to Clear on Aβ-Degrading Enzymes?

RESEARCH NEWS 2001-11-11 Research News There are two principal ways by which the Aβ accumulation seen in the brains of people with AD can occur. One-overproduction by β- and γ-secretases-has received far more attention than the other-insufficient clearance of the offending ...

Aβ Vaccination Roundup: So Far So Good

RESEARCH NEWS 2001-11-11 Research News On this second day of the conference, scientists gave an update on the current status of Aβ vaccination. Since researchers at Elan Pharmaceuticals in 1999 first demonstrated the basic principle to immunize against Aβ in the hope of clearing ...

Dopamine and α-Synuclein Are Found to Be Chemically Linked

RESEARCH NEWS 2001-11-09 Research News Both the protein α-synuclein, one of the major components of Lewy bodies, and the neurotransmitter dopamine have come under scrutiny as potential mediators of the neuronal loss in the substantia nigra that occurs in Parkinson's disease. ...

Axonal Transport Suggested as Function for APP

RESEARCH NEWS 2001-11-09 Research News A study in yesterday's Neuron suggests that Alzheimer's disease might be linked to a disruption of protein transport machinery in neurons. Shermali Gunawardena and Lawrence Goldstein at UC San Diego provide evidence to support the ...

Larry Sparks on Neurons Need Cholesterol from Glia to Make Synapses

COMMENT The compelling data by Mauch et al. affirms the critical nature of cholesterol in the CNS, particularly the developing CNS. As with most very good research, the experiments lead to important answers and provide the foundation for more questions. These ...

David Holtzman on Neurons Need Cholesterol from Glia to Make Synapses

COMMENT Mauch et al., in a well-designed, interesting study, demonstrate the importance of cholesterol to the formation of electrically functional synapses in cultured retinal ganglion cells. They demonstrate that retinal ganglion cells attain their normal ...

Anti-inflammatory Drugs Side-Step COX Cascade to Target Aβ

RESEARCH NEWS 2001-11-08 Research News If anti-inflammatory drugs are, in fact, helping some patients counteract the neurodegeneration of Alzheimer's disease, the benefit may not come from the most obvious effects of those drugs. Eddie Koo and Sascha Weggen of the University ...

Neurons Need Cholesterol from Glia to Make Synapses

RESEARCH NEWS 2001-11-08 Research News Cholesterol and apolipoproteins in Alzheimer's disease have become a rapidly developing-and sometimes confusing-area of investigation, but most of it suggests that lowering cholesterol might slow disease progression. A paper in tomorrow ...

PET Found to Be a Specific and Sensitive Tool for Diagnosis of Alzheimer's Disease

RESEARCH NEWS 2001-11-07 Research News Numerous studies have shown that positron emission tomography (PET) can reveal small metabolic changes in the brains of patients with neurodegenerative disorders, particularly Alzheimer's disease. However, the paucity of cases examined ...

PAPER Kim KW, Jhoo JH, Lee KU, Lee DY, Lee JH, Youn JY, Lee BJ, Han SH, Woo JI

Association between apolipoprotein E polymorphism and Alzheimer's disease in Koreans.

Neurosci Lett. 1999 Dec 31;277(3):145-8. PubMed: 10626834

PAPER Lezoualc'h F, Engert S, Berning B, Behl C

Corticotropin-releasing hormone-mediated neuroprotection against oxidative stress is associated with the increased release of non-amyloidogenic amyloid beta precursor protein and with the suppression of nuclear factor-kappaB.

Mol Endocrinol. 2000 Jan;14(1):147-59. PubMed: 10628754

PAPER Siman R, Reaume AG, Savage MJ, Trusko S, Lin YG, Scott RW, Flood DG

Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability.

J Neurosci. 2000 Dec 1;20(23):8717-26. PubMed: 11102478

PAPER García-Jiménez A, Cowburn RF, Ohm TG, Bogdanovic N, Winblad B, Fastbom J

Quantitative autoradiography of [3H]forskolin binding sites in post-mortem brain staged for Alzheimer's disease neurofibrillary changes and amyloid deposits.

Brain Res. 1999 Dec 11;850(1-2):104-17. PubMed: 10629754

PAPER Monk D, Brodaty H

Use of estrogens for the prevention and treatment of Alzheimer's disease.

Dement Geriatr Cogn Disord. 2000 Jan-Feb;11(1):1-10. PubMed: 10629355

PAPER Scherder EJ, Bouma A

Acute versus chronic pain experience in Alzheimer's disease. a new questionnaire.

Dement Geriatr Cogn Disord. 2000 Jan-Feb;11(1):11-6. PubMed: 10629356