PAPER Irish M, Cunningham CJ, Walsh JB, Coakley D, Lawlor BA, Robertson IH, Coen RF
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PAPER Oshima K, Akiyama H, Tsuchiya K, Kondo H, Haga C, Shimomura Y, Iseki E, Uchikado H, Kato M, Niizato K, Arai H
Relative paucity of tau accumulation in the small areas with abundant Abeta42-positive capillary amyloid angiopathy within a given cortical region in the brain of patients with Alzheimer pathology.
Acta Neuropathol. 2006 Jun;111(6):510-8. PubMed: 16718347PAPER Castellani RJ, Lee HG, Zhu X, Nunomura A, Perry G, Smith MA
Neuropathology of Alzheimer disease: pathognomonic but not pathogenic.
Acta Neuropathol. 2006 Jun;111(6):503-9. PubMed: 16718346RAGE
ANTIBODY polyclonal manufacturer cat# PA1-38535 immunogen = synthetic peptide corresp. to residues 38-57 of human RAGE liquid, epitope affinity purified, PBS, BSA, azide detects RAGE IgG AGE & RAGE A B R- Thermo Scientific Rabbit Human Mouse Rat RAGE http://al
RAGE
ANTIBODY polyclonal manufacturer cat # <br />PA1-23061 immunogen = synthetic peptide R A E L N Q S E E P E A G E S, corresp. to C-terminal amino acids 385-399 of human RAGE liquid, whole antisera RAGE AGE & RAGE A B R- Thermo Scientific Goat Human RAGE h
RAGE
ANTIBODY polyclonal manufacturer cat # PA1-075 immunogen = synthetic peptide, C(362)W R K R Q P R(R/L) E E R K A P E S Q E D (N) (380) rat RAGE liquid, affinity purified, PBS, BSA, azide RAGE AGE & RAGE A B R- Thermo Scientific Rabbit Mouse Rat RAGE http://alz
Shirley ShiDu Yan on Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression.
COMMENT This paper supports our recently described studies on Aβ-binding alcohol dehydrogenase (ABAD), Aβ, and mitochondrial toxicity (see Lustbader et al., 2004; Caspersen et al., 2005; and Takuma et al., 2005). In our Science paper (see Lustbader et al., 2004),
Sanjay Pimplikar on Paper Alert: Pathology Reversed by Abolishing APP Caspase Site
COMMENT APP Cytoplasmic Domain: An Orphan No More! A central tenet of the “amyloid cascade hypothesis” posits that Aβ peptides are the causative agent of AD pathogenesis. Although the details remain sketchy, the amyloid hypothesis suggests that abnormal accumulat
Bernadette Allinquant on San Diego: AβPP—Can the Tail Wag the Dog?
COMMENT The study by Galvan et al. is the first to show the involvement of APP cytoplasmic caspase cleavage in the development of AD pathology. The authors substituted the aspartate at position 664 of APP with an alanine in a minigene carrying familial AD mutated
Bart De Strooper on Gain or Loss of Function—Time to Shake up Assumptions on γ-Secretase in Alzheimer Disease?
COMMENT It was a great idea to have this discussion online. Different views have confronted each other in a friendly way, and I think the conclusion of the debate is indeed that no simple answer is available at this moment. We clearly need further understanding o
Joan Amatniek
Ortho-McNeil NeurologicsTitusville, United States
Vincent Marchesi on Gain or Loss of Function—Time to Shake up Assumptions on γ-Secretase in Alzheimer Disease?
COMMENT Peter Davies was too modest to proclaim, as he did in his closing comment, that he would be happy if many people recognized that the mechanisms by which presenilin mutations cause Alzheimer disease may be more complicated than the simple increase in Aβ pr
PAPER Lippa CF, Smith TW, Nee L, Robitaille Y, Crain B, Dickson D, Pulaski-Salo D, Pollen DA
Familial Alzheimer's disease and cortical Lewy bodies: is there a genetic susceptibility factor?
Dementia. 1995 Jul-Aug;6(4):191-4. PubMed: 7550597PAPER Flanders KC, Lippa CF, Smith TW, Pollen DA, Sporn MB
Altered expression of transforming growth factor-beta in Alzheimer's disease.
Neurology. 1995 Aug;45(8):1561-9. PubMed: 7543987PAPER Lippa CF, Saunders AM, Smith TW, Swearer JM, Drachman DA, Ghetti B, Nee L, Pulaski-Salo D, Dickson D, Robitaille Y, Bergeron C, Crain B, Benson MD, Farlow M, Hyman BT, George-Hyslop SP, Roses AD, Pollen DA
Familial and sporadic Alzheimer's disease: neuropathology cannot exclude a final common pathway.
Neurology. 1996 Feb;46(2):406-12. PubMed: 8614503Current Filters
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