PAPER Grillo P, Sancesario GM, Bovenzi R, Zenuni H, Bissacco J, Mascioli D, Simonetta C, Forti P, Degoli GR, Pieri M, Chiurchiù V, Stefani A, Mercuri NB, Schirinzi T

Neutrophil-to-lymphocyte ratio and lymphocyte count reflect alterations in central neurodegeneration-associated proteins and clinical severity in Parkinson Disease patients.

Parkinsonism Relat Disord. 2023 Jul;112:105480. Epub 2023 Jun 4 PubMed: 37290213

PAPER Bukhbinder AS, Ling Y, Harris K, Jiang X, Schulz PE

Do vaccinations influence the development of Alzheimer disease?

Hum Vaccin Immunother. 2023 Aug 1;19(2):2216625. Epub 2023 Jun 8 PubMed: 37291109

PAPER Pinho J, Almeida FC, Araújo JM, Machado Á, Costa AS, Silva F, Francisco A, Quintas-Neves M, Ferreira C, Soares-Fernandes JP, Oliveira TG

Sex-Specific Patterns of Cerebral Atrophy and Enlarged Perivascular Spaces in Patients with Cerebral Amyloid Angiopathy and Dementia.

AJNR Am J Neuroradiol. 2023 Jul;44(7):792-798. Epub 2023 Jun 8 PubMed: 37290817

PAPER Kim M, Bezprozvanny I

Potential direct role of synuclein in dopamine transport and its implications for Parkinson's disease pathogenesis.

Biochem Biophys Res Commun. 2023 Sep 3;671:18-25. Epub 2023 Jun 7 PubMed: 37290280

PAPER Schultz SA, Shirzadi Z, Schultz AP, Liu L, Fitzpatrick CD, McDade E, Barthelemy NR, Renton A, Esposito B, Joseph-Mathurin N, Cruchaga C, Chen CD, Goate A, Allegri RF, Benzinger TL, Berman S, Chui HC, Fagan AM, Farlow MR, Fox NC, Gordon BA, Day GS, Graff-Radford NR, Hassenstab JJ, Hanseeuw BJ, Hofmann A, Jack CR Jr, Jucker M, Karch CM, Koeppe RA, Lee JH, Levey AI, Levin J, Martins RN, Mori H, Morris JC, Noble J, Perrin RJ, Rosa-Neto P, Salloway SP, Sanchez-Valle R, Schofield PR, Xiong C, Johnson KA, Bateman RJ, Sperling RA, Chhatwal JP, Dominantly Inherited Alzheimer Network Investigators

Location of pathogenic variants in PSEN1 impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal-dominant Alzheimer's disease.

Aging Cell. 2023 Aug;22(8):e13871. Epub 2023 Jun 8 PubMed: 37291760

PAPER Dou J, Bakulski K, Guo K, Hur J, Zhao L, Saez-Atienzar S, Stark A, Chia R, García-Redondo A, Rojas-Garcia R, Vázquez Costa JF, Fernandez Santiago R, Bandres-Ciga S, Gómez-Garre P, Periñán MT, Mir P, Pérez-Tur J, Cardona F, Menendez-Gonzalez M, Riancho J, Borrego-Hernández D, Galán-Dávila L, Infante Ceberio J, Pastor P, Paradas C, Dols-Icardo O, Traynor BJ, Feldman EL, Goutman SA, Spanish Neurological Consortium

Cumulative Genetic Score and C9orf72 Repeat Status Independently Contribute to Amyotrophic Lateral Sclerosis Risk in 2 Case-Control Studies.

Neurol Genet. 2023 Aug;9(4):e200079. Epub 2023 May 31 PubMed: 37293291

PAPER Chacko L, Chaudhary A, Singh B, Dewanjee S, Kandimalla R

CRISPR-Cas9 in Alzheimer's disease: Therapeutic trends, modalities, and challenges.

Drug Discov Today. 2023 Aug;28(8):103652. Epub 2023 Jun 7 PubMed: 37290639

PAPER Broos JY, Loonstra FC, de Ruiter LR, Gouda M, Fung WH, Schoonheim MM, Heijink M, Strijbis EM, Teunissen C, Killestein J, de Vries HE, Giera M, Uitdehaag BM, Kooij G

Association of Arachidonic Acid-Derived Lipid Mediators With Disease Severity in Patients With Relapsing and Progressive Multiple Sclerosis.

Neurology. 2023 Aug 1;101(5):e533-e545. Epub 2023 Jun 8 PubMed: 37290971

PAPER Yin Z, Herron S, Silveira S, Kleemann K, Gauthier C, Mallah D, Cheng Y, Margeta MA, Pitts KM, Barry JL, Subramanian A, Shorey H, Brandao W, Durao A, Delpech JC, Madore C, Jedrychowski M, Ajay AK, Murugaiyan G, Hersh SW, Ikezu S, Ikezu T, Butovsky O

Identification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer's disease.

Nat Neurosci. 2023 Jul;26(7):1196-1207. Epub 2023 Jun 8 PubMed: 37291336

Shrunken FDA Advisory Committee Is Unanimous: Leqembi Works

COMMUNITY NEWS 2023-06-09 Community News A Food and Drug Administration advisory committee today recommended traditional approval of Eisai’s anti-amyloid antibody lecanemab. On the sole voting question before it, the six-member committee unanimously agreed that lecanemab’s Phase 3

Tsuneya Ikezu on Multiomic Analysis Shows Lysosomes Need Retromer to Stay Healthy

COMMENT This is a highly comprehensive, cell-based study using multi-omic approaches to understand how Vps35 deficiency leads to the accumulation of lysosomal components. The use of HA-tagged Tmem192 for lysosomal tagging to perform LysoIP is a novel approach tha

Investigator-Initiated Research in Genomics and Health Equity (R01 Clinical Trial Optional) (RFA-HG-23-017)

GRANT Friday, June 9, 2023- 3:45pm National Institutes of Health Multiple due dates; see announcement. https://grants.nih.gov/grants/guide/rfa-files/RFA-HG-23-017.html 09 Jul 2025

Investigator-Initiated Research in Genomics and Health Equity (R21 Clinical Trial Optional) (RFA-HG-23-018)

GRANT Friday, June 9, 2023- 3:45pm National Institutes of Health Multiple due dates; see announcement. https://grants.nih.gov/grants/guide/rfa-files/RFA-HG-23-018.html 09 Jul 2025

Dimitrios Kapogiannis on Multiomic Analysis Shows Lysosomes Need Retromer to Stay Healthy

COMMENT Retromer abnormalities have been implicated in Alzheimer’s disease pathogenesis, but the exact mechanisms remain unclear. This new study by Daly et al. offers valuable new insights by linking retromer with endo-lysosomal system health; specifically, the s

Jessica Young on Multiomic Analysis Shows Lysosomes Need Retromer to Stay Healthy

COMMENT The association of the multi-protein sorting complex, retromer, with neurodegenerative disorders, such as AD and PD, has long been known. The immense complexity of the pathway, however, makes dissecting the mechanisms of this association challenging. This