PAPER Barba L, Abu-Rumeileh S, Halbgebauer S, Bellomo G, Paolini Paoletti F, Gaetani L, Oeckl P, Steinacker P, Massa F, Parnetti L, Otto M
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PAPER Du J, Li A, Shi D, Chen X, Wang Q, Liu Z, Sun K, Guo T, Alzheimer's Disease Neuroimaging Initiative
Association of APOE-ε4, Osteoarthritis, β-Amyloid, and Tau Accumulation in Primary Motor and Somatosensory Regions in Alzheimer Disease.
Neurology. 2023 Jul 4;101(1):e40-e49. Epub 2023 May 15 PubMed: 37188537PAPER Cui L, Zhang Z, Huang YL, Xie F, Guan YH, Lo CZ, Guo YH, Jiang JH, Guo QH
Brain amyloid-β deposition associated functional connectivity changes of ultra-large structural scale in mild cognitive impairment.
Brain Imaging Behav. 2023 Oct;17(5):494-506. Epub 2023 May 16 PubMed: 37188840PAPER Tumurbaatar B, Fracassi A, Scaduto P, Guptarak J, Woltjer R, Jupiter D, Taglialatela G
Preserved autophagy in cognitively intact non-demented individuals with Alzheimer's neuropathology.
Alzheimers Dement. 2023 May 16; PubMed: 37191183PAPER Babić Leko M, Langer Horvat L, Španić Popovački E, Zubčić K, Hof PR, Šimić G
Metals in Alzheimer's Disease.
Biomedicines. 2023 Apr 12;11(4) PubMed: 37189779PAPER Mirkin S, Albensi BC
Should artificial intelligence be used in conjunction with Neuroimaging in the diagnosis of Alzheimer's disease?
Front Aging Neurosci. 2023;15:1094233. Epub 2023 Apr 18 PubMed: 37187577PAPER Koretsky MJ, Alvarado C, Makarious MB, Vitale D, Levine K, Bandres-Ciga S, Dadu A, Scholz SW, Sargent L, Faghri F, Iwaki H, Blauwendraat C, Singleton A, Nalls M, Leonard H
Genetic risk factor clustering within and across neurodegenerative diseases.
Brain. 2023 Nov 2;146(11):4486-4494. PubMed: 37192343PAPER Calafate S, Özturan G, Thrupp N, Vanderlinden J, Santa-Marinha L, Morais-Ribeiro R, Ruggiero A, Bozic I, Rusterholz T, Lorente-Echeverría B, Dias M, Chen WT, Fiers M, Lu A, Vlaeminck I, Creemers E, Craessaerts K, Vandenbempt J, van Boekholdt L, Poovathingal S, Davie K, Thal DR, Wierda K, Oliveira TG, Slutsky I, Adamantidis A, De Strooper B, de Wit J
Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer's disease.
Nat Neurosci. 2023 Jun;26(6):1021-1031. Epub 2023 May 15 PubMed: 37188873Karyn Frick
University of Wisconsin-MilwaukeeMilwaukee, United States
Victor Montal on Reelin Variant Wards Off Dementia in Colombian Kindred Siblings
COMMENT Lopera and colleagues showcase the importance of studying rare mutations in large, well-characterized populations as the Colombian ADAD cohort. Three points caught my attention. First, the sex differences between the siblings and also in animal models. A
Gael Nicolas on Reelin Variant Wards Off Dementia in Colombian Kindred Siblings
COMMENT Looking for modifiers of age of clinical onset in PSEN1-mutation carriers is a very interesting and important aim, as it helps us better understand AD pathophysiology and could point toward actionable targets for disease modification. This task is difficu
Reelin Variant Wards Off Dementia in Colombian Kindred Siblings
RESEARCH NEWS 2023-05-16 Research News A Colombian brother and sister staved off autosomal-dominant Alzheimer’s disease for 20 years past the age of onset expected based on their inheritance of the E280A Paisa presenilin mutation, according to a new case report. That is thanks to
Mitsuharu Hattori, Takao Kohno on Reelin Variant Wards Off Dementia in Colombian Kindred Siblings
COMMENT This is the first causal link between Reelin activity and AD, and the first gain-of-function Reelin mutation in humans. That a point mutation in Reelin’s C-terminal region increases activity is surprising. It is even more surprising that such a small diff
Inmaculada Cuchillo Ibañez on Reelin Variant Wards Off Dementia in Colombian Kindred Siblings
COMMENT This extensive and comprehensive article includes a huge variety of methodological approaches both in vivo and in vitro to explore the effect of the RELN-COLBOS mutation on the reelin signaling pathway. To further include the data on the total levels of D
Jason Ulrich on Reelin Variant Wards Off Dementia in Colombian Kindred Siblings
COMMENT This is another exciting discovery from the Colombia-Boston collaboration identifying potential protective genetic factors in ADAD carriers. These unique genetic examples provide valuable insight into new biology regarding how amyloid pathology can facili
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