PAPER Mancuso C, Scapagini G, Currò D, Giuffrida Stella AM, De Marco C, Butterfield DA, Calabrese V
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Mark Cookson on The familial Parkinsonism gene LRRK2 regulates neurite process morphology.
COMMENT This paper shows in a striking way that the Lrrk2 gene, which is associated with dominantly inherited PD in humans, has dramatic effects on neuronal morphology in vitro and in vivo. A key point from this study is that the kinase activity is critical for m
PAPER MacLeod D, Dowman J, Hammond R, Leete T, Inoue K, Abeliovich A
The familial Parkinsonism gene LRRK2 regulates neurite process morphology.
Neuron. 2006 Nov 22;52(4):587-93. PubMed: 17114044Mary Reid on SfN: The Old and the New—BACE and Cathepsin B Share the β-secretase Stage
COMMENT Taha and colleagues (1) find that sphingosine kinase-1 is a substrate for cathepsin B. I note the studies by the Iribarren and Kaneider groups (2,3) and wonder about the effect of cathepsin B inhibitors on formyl peptide receptor-like-1/sphingosine kinase
PAPER Taha TA, El-Alwani M, Hannun YA, Obeid LM
Sphingosine kinase-1 is cleaved by cathepsin B in vitro: identification of the initial cleavage sites for the protease.
FEBS Lett. 2006 Nov 13;580(26):6047-54. PubMed: 17064696Ruth Itzhaki on Disrupted spatial memory is a consequence of picornavirus infection.
COMMENT We would like to add to Brian Balin’s interesting comment that encephalitis and hippocampal damage have been associated with picornaviruses, which could have implications for Alzheimer disease (AD). In fact a number of other viruses—of diverse types—can c
PAPER Jamieson GA, Maitland NJ, Wilcock GK, Yates CM, Itzhaki RF
Herpes simplex virus type 1 DNA is present in specific regions of brain from aged people with and without senile dementia of the Alzheimer type.
J Pathol. 1992 Aug;167(4):365-8. PubMed: 1328575A. David Smith on Could linear MRI measurements of hippocampus differentiate normal brain aging in elderly persons from Alzheimer disease?
COMMENT It is surprising to read a paper with this title in 2006. It was shown in 1992 that the answer to the question posed in the title is “Yes,” if CT is used instead of MRI (Jobst et al., 1992). The latter paper showed that the medial temporal lobe shrinks wi
PAPER Seab JP, Jagust WJ, Wong ST, Roos MS, Reed BR, Budinger TF
Quantitative NMR measurements of hippocampal atrophy in Alzheimer's disease.
Magn Reson Med. 1988 Oct;8(2):200-8. PubMed: 3210957PAPER Jobst KA, Smith AD, Szatmari M, Esiri MM, Jaskowski A, Hindley N, McDonald B, Molyneux AJ
Rapidly progressing atrophy of medial temporal lobe in Alzheimer's disease.
Lancet. 1994 Apr 2;343(8901):829-30. PubMed: 7908080PAPER Jobst KA, Smith AD, Szatmari M, Molyneux A, Esiri ME, King E, Smith A, Jaskowski A, McDonald B, Wald N
Detection in life of confirmed Alzheimer's disease using a simple measurement of medial temporal lobe atrophy by computed tomography.
Lancet. 1992 Nov 14;340(8829):1179-83. PubMed: 1359259PAPER de Leon MJ, George AE, Stylopoulos LA, Smith G, Miller DC
Early marker for Alzheimer's disease: the atrophic hippocampus.
Lancet. 1989 Sep 16;2(8664):672-3. PubMed: 2570916Grb2 (4C6-H6)
ANTIBODY monoclonal 4C6-H6 manufacturer Cat# H00002885-M01<br />supplied by Abnova <br /> available in North America only immunogen = full length recombinant GRB2 liquid, ascites, no preservative GRB2- growth factor receptor-bound protein 2 IgM,κ Cell
SH3GLB1 (1B3-A5)
ANTIBODY monoclonal 1B3-A5 manufacturer Cat# H00051100-M01<br />supplied by Abnova <br /> available in North America only immunogen = full length recombinant SH3GLB1 liquid, purified, no preservative SH3GLB1- SH3-domain GRB2-like endophilin B1 IgG<s
SH3GL2 (5A6)
ANTIBODY monoclonal 5A6 manufacturer Cat# H00006456-M01<br />supplied by Abnova <br /> available in North America only immunogen = partial recombinant SH3GL2 liquid, purified, no preservative SH3GL2- SH3-domain GRB2-like 2 IgG<sub>2a</sub>,
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