PAPER Baki L, Neve RL, Shao Z, Shioi J, Georgakopoulos A, Robakis NK

Wild-type but not FAD mutant presenilin-1 prevents neuronal degeneration by promoting phosphatidylinositol 3-kinase neuroprotective signaling.

J Neurosci. 2008 Jan 9;28(2):483-90. PubMed: 18184791

PAPER Baloh RH, Schmidt RE, Pestronk A, Milbrandt J

Altered axonal mitochondrial transport in the pathogenesis of Charcot-Marie-Tooth disease from mitofusin 2 mutations.

J Neurosci. 2007 Jan 10;27(2):422-30. PubMed: 17215403

PAPER Das S, Gerwin C, Sheng ZH

Syntaphilin binds to dynamin-1 and inhibits dynamin-dependent endocytosis.

J Biol Chem. 2003 Oct 17;278(42):41221-6. PubMed: 12896979

PAPER Jonas E

BCL-xL regulates synaptic plasticity.

Mol Interv. 2006 Aug;6(4):208-22. PubMed: 16960143

PAPER Lao G, Scheuss V, Gerwin CM, Su Q, Mochida S, Rettig J, Sheng ZH

Syntaphilin: a syntaxin-1 clamp that controls SNARE assembly.

Neuron. 2000 Jan;25(1):191-201. PubMed: 10707983

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Mikko Laakso on Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial.

COMMENT I don't understand how this can be a milestone paper. Where is the criticism of the scientific community? This paper is likely to cause great damage among the female population in terms of increased AD in the future. The study setting is questionable

Gabrielle Strobel on Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial.

COMMENT Reply by Alzforum Editors to Comment by Mikko Laakso The election of this paper by Alzforum readers represents an example of where the Milestone status reflects not so much an endorsement of a study, but an acknowledgment that the paper has changed the fi

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