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Thomas Wisniewski on Presenilin Loss of Function—Plan B for AD?

COMMENT The emerging evidence suggests that the role of PS FAD-associated mutations involves not only a gain of negative function via APP processing but also a loss of function. Although there is vast evidence to suggest that APP processing and clearance plays a

DJ-1 (E.2)

ANTIBODY monoclonal E.2 manufacturer Cat# 05-828 immunogen = GST fusion protein corresponding to full length human DJ-1 liquid, ascites, azide, glycerol DJ-1 others not tested IgM DJ-1 Upstate and Chemicon are Millipore Mouse Human DJ-1 http://alzforum.org/res/com

DJ-1/PARK7

ANTIBODY monoclonal manufacturer Cat# MAB5546 immunogen = full length recombinant DJ1 liquid, ascites, no preservative DJ1 (PARK7) others not tested IgM DJ-1 Chemicon and Upstate are Millipore Mouse Human DJ-1/PARK7 http://alzforum.org/res/com/ant/default.asp?anti

DJ-1/PARK7

ANTIBODY polyclonal manufacturer Cat# AB9212 immunogen = synthetic peptide from human DJ-1 liquid DJ-1 (PARK7) others not tested DJ-1 Chemicon and Upstate are Millipore Rabbit Human DJ-1/PARK7 http://alzforum.org/res/com/ant/default.asp?antibodyID=20942

CaM Kinase II

ANTIBODY kit manufacturer Cat# 32-009 FP Fluorescein Green Assay CaM Kinase II Kinase assay CaM Kinase II (CAMKII) Upstate and Chemicon are Millipore Unknown Host CaM Kinase II http://alzforum.org/res/com/ant/default.asp?antibodyID=20940

CaM Kinase II

ANTIBODY kit manufacturer Cat# 32-089 FP-645nm FarRed Assay CaM Kinase II Kinase assay CaM Kinase II (CAMKII) Upstate and Chemicon are Millipore Unknown Host CaM Kinase II http://alzforum.org/res/com/ant/default.asp?antibodyID=20939

CREB pSer133 and ATF1 pSer63 (AOW13)

ANTIBODY monoclonal AOW13 manufacturer Cat# 05-948 Immunogen = KLH-conjugated, synthetic peptide containing the sequence RPpSY in which [pS] corresp. to serine at residues 63 of human ATF1 and 133 of human CREB liquid, protein-A, Tris, glycerol, azide CREB phospho

CREB (NL904)

ANTIBODY monoclonal NL904 manufacturer Cat# 05-767 immunogen = synthetic peptide, C S G E N Q Q S G D A A V T E A E N Q Q, corresp. to aa 5-24 of human CREB liquid, tris-saline, BSA, azide, glycerol, Protein A purified CREB (~43kDa). A non-specific protein was als

CaM Kinase II, γ subunit

ANTIBODY polyclonal manufacturer Cat# 07-743 Immunogen = 6His-tagged fusion protein corresp. to residues 7-305 of ferret CaM Kinase II, γ subunit liquid, affinity purified, Tris, glycerol, azide CaM Kinase II γ-subunit IgG CaM Kinase II (CAMKII) Upstate and Chemic

COX-1

ANTIBODY polyclonal manufacturer Cat# 06-970 immunogen = purified ram seminal vesicles frozen liquid, protein-A, PBS, BSA, merthiolate COX-1; no cross reaction with COX-2 others not tested, but should detect other mammalian IgG COX1, COX2, COX3, COX IV Upstate and

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