PAPER Li Y, Liu L, Kang J, Sheng JG, Barger SW, Mrak RE, Griffin WS

Neuronal-glial interactions mediated by interleukin-1 enhance neuronal acetylcholinesterase activity and mRNA expression.

J Neurosci. 2000 Jan 1;20(1):149-55. PubMed: 10627591

Henry Querfurth on Double Paper Alert—A Function for BACE, a Basis for Amyloid

COMMENT It’s a Wrap; Axonal Myelination Is Regulated by the Alzheimer Disease Target, BACE A fundamental developmental process has once again crossed paths with a major player in the pathogenesis of Alzheimer disease. Shortly after its discovery, BACE, via its in

PAPER Di Segni A, Shaharabani E, Stein R, Pinkas-Kramarski R

Neuregulins rescue PC12-ErbB-4 cells from cell death induced by beta-amyloid peptide: involvement of PI3K and PKC.

J Mol Neurosci. 2005;26(1):57-69. PubMed: 15968086

PAPER Bao J, Wolpowitz D, Role LW, Talmage DA

Back signaling by the Nrg-1 intracellular domain.

J Cell Biol. 2003 Jun 23;161(6):1133-41. PubMed: 12821646

PAPER Hu X, Hicks CW, He W, Wong P, Macklin WB, Trapp BD, Yan R

Bace1 modulates myelination in the central and peripheral nervous system.

Nat Neurosci. 2006 Dec;9(12):1520-5. Epub 2006 Nov 12 PubMed: 17099708

PAPER Li Y, Tennekoon GI, Birnbaum M, Marchionni MA, Rutkowski JL

Neuregulin signaling through a PI3K/Akt/Bad pathway in Schwann cell survival.

Mol Cell Neurosci. 2001 Apr;17(4):761-7. PubMed: 11312610

PAPER Flores AI, Mallon BS, Matsui T, Ogawa W, Rosenzweig A, Okamoto T, Macklin WB

Akt-mediated survival of oligodendrocytes induced by neuregulins.

J Neurosci. 2000 Oct 15;20(20):7622-30. PubMed: 11027222

PAPER Maurel P, Salzer JL

Axonal regulation of Schwann cell proliferation and survival and the initial events of myelination requires PI 3-kinase activity.

J Neurosci. 2000 Jun 15;20(12):4635-45. PubMed: 10844033

PAPER Ogata T, Iijima S, Hoshikawa S, Miura T, Yamamoto S, Oda H, Nakamura K, Tanaka S

Opposing extracellular signal-regulated kinase and Akt pathways control Schwann cell myelination.

J Neurosci. 2004 Jul 28;24(30):6724-32. PubMed: 15282275

PAPER Chen S, Velardez MO, Warot X, Yu ZX, Miller SJ, Cros D, Corfas G

Neuregulin 1-erbB signaling is necessary for normal myelination and sensory function.

J Neurosci. 2006 Mar 22;26(12):3079-86. PubMed: 16554459

PAPER Taveggia C, Zanazzi G, Petrylak A, Yano H, Rosenbluth J, Einheber S, Xu X, Esper RM, Loeb JA, Shrager P, Chao MV, Falls DL, Role L, Salzer JL

Neuregulin-1 type III determines the ensheathment fate of axons.

Neuron. 2005 Sep 1;47(5):681-94. PubMed: 16129398

Thomas Wisniewski on Presenilin Loss of Function—Plan B for AD?

COMMENT The emerging evidence suggests that the role of PS FAD-associated mutations involves not only a gain of negative function via APP processing but also a loss of function. Although there is vast evidence to suggest that APP processing and clearance plays a

DJ-1 (E.2)

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