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Joseph Lewcock, Kathryn Monroe on Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer's disease.
COMMENT This manuscript adds to the growing body of work supporting antibody-mediated agonism of TREM2 as a therapeutic approach for treatment of Alzheimer’s disease. These results are consistent with other studies demonstrating the impact of distinct TREM2 ...
Marco Colonna, Daniel Ellwanger, Menno van Lookeren Campagne, Shoutang Wang on Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer's disease.
COMMENT We thank Drs. Haass and Schlepckow for their comment. We agree that TREM2 agonist antibodies have been developed by other groups, an excellent body of work that we referenced and discussed in our paper. We would like to emphasize several points: First, ...
Thomas Beach, Diego Mastroeni, Geidy Serrano, Matt Huentelman on Selective Vulnerability News: RORB Neurons Are First Victims of Tangles
COMMENT This report is intriguing and reinforces the power of single-nucleus studies of human postmortem brain tissue for understanding neurodegenerative disease. The identification of RORB as a possibly critical protein associated with selective vulnerability ...
PAPER Zhu Y, Wang L, Yin Y, Yang E
Systematic analysis of gene expression patterns associated with postmortem interval in human tissues.Sci Rep. 2017 Jul 14;7(1):5435. PubMed: 28710439
PAPER Stamper C, Siegel A, Liang WS, Pearson JV, Stephan DA, Shill H, Connor D, Caviness JN, Sabbagh M, Beach TG, Adler CH, Dunckley T18649390
PAPER Kang SS, Baker KE, Wang X, Kocher J-, Fryer JD
PAPER Serrano GE, Walker JE, Intorcia AJ, Glass MJ, Arce RA, Piras IS, Talboom JS, Nelson CM, Cutler BD, Sue LI, Lue L-, Huentelman M, Beach TG
PAPER Jung H, Holt CE21956974
PAPER Jung H, Gkogkas CG, Sonenberg N, Holt CE24679524
PAPER Timmers HT, Tora L30290147
COMMENT In Alzheimer’s disease, which is so complex, selective cellular vulnerability is a key anchoring point for mechanistic discovery. To leverage it, we must understand what differs between vulnerable and spared cells as disease progresses. Single-nuclear RNA ...
RESEARCH NEWS 2021-01-21 Research News As Alzheimer’s tangle pathology progresses, neurodegeneration sweeps through the brain in a stereotypical fashion. But why do some neurons perish early on, while their neighbors persist until the bitter end? A study published January 11 in ...