RESEARCH NEWS 2019-10-17 Research News Researchers for years thought that tau was a natively unstructured protein. Then how in the world do its supposedly disordered monomers give rise to the orderly stacks of tau molecules seen in tau fibrils? Using chemical cross-linkers to ...
PAPER Popov KI, Makepeace KA, Petrotchenko EV, Dokholyan NV, Borchers CH
PAPER Brodie NI, Popov KI, Petrotchenko EV, Dokholyan NV, Borchers CH
Solving protein structures using short-distance cross-linking constraints as a guide for discrete molecular dynamics simulations.Sci Adv. 2017 Jul;3(7):e1700479. Epub 2017 Jul 7 PubMed: 28695211
RESEARCH NEWS 2019-10-17 Research News ApoE4 delivers a blow to neurons in mouse models of tauopathy but, according to a paper published October 10 in the Journal of Experimental Medicine, it only does so if mice have their microglia. Researchers led by David Holtzman at ...
THERAPEUTICS AstraZeneca Takeda Pharmaceutical Company Immunotherapy (passive) alpha-synuclein In October 2017, Astra Zeneca began a Phase 1 single-ascending-dose study in 48 healthy volunteers age 18 to 65. Each volunteer receives a one-hour intravenous infusion of ...
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PAPER Tobey H, Lucas T, Bledsoe D, Mykins M, Campbell C, Berr SS, Sasser T, Helm R, Brolinson PG, Klein BG, Costa BM31613309
PAPER Gao Q, Wang Y, Wang X, Fu S, Zhang X, Wang RT, Zhang X
Decreased levels of circulating trimethylamine N-oxide alleviate cognitive and pathological deterioration in transgenic mice: a potential therapeutic approach for Alzheimer's disease.Aging (Albany NY). 2019 Oct 14;11 PubMed: 31612864
PAPER Ramalingam M, Huh YJ, Lee YI
The Impairments of α-Synuclein and Mechanistic Target of Rapamycin in Rotenone-Induced SH-SY5Y Cells and Mice Model of Parkinson's Disease.Front Neurosci. 2019;13:1028. Epub 2019 Sep 24 PubMed: 31611767
PAPER Laflamme C, McKeever PM, Kumar R, Schwartz J, Kolahdouzan M, Chen CX, You Z, Benaliouad F, Gileadi O, McBride HM, Durcan TM, Edwards AM, Healy LM, Robertson J, McPherson PS
Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72.Elife. 2019 Oct 15;8 PubMed: 31612854
PAPER Hodgins F, Mulhern S, Abrahams S