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Molecular Transport Vehicle Shuttles Therapies into Brain

RESEARCH NEWS 2020-05-29 Research News Researchers have devised a new way to sneak therapeutic cargo across the blood-brain barrier. Into the constant region of a human IgG1 antibody, they slid a domain that latches onto receptors that carry transferrin into the brain. On the ...

PAPER Ullman JC, Arguello A, Getz JA, Bhalla A, Mahon CS, Wang J, Giese T, Bedard C, Kim DJ, Blumenfeld JR, Liang N, Ravi R, Nugent AA, Davis SS, Ha C, Duque J, Tran HL, Wells RC, Lianoglou S, Daryani VM, Kwan W, Solanoy H, Nguyen H, Earr T, Dugas JC, Tuck MD, Harvey JL, Reyzer ML, Caprioli RM, Hall S, Poda S, Sanchez PE, Dennis MS, Gunasekaran K, Srivastava A, Sandmann T, Henne KR, Thorne RG, Di Paolo G, Astarita G, Diaz D, Silverman AP, Watts RJ, Sweeney ZK, Kariolis MS, Henry AG

Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice.

Sci Transl Med. 2020 May 27;12(545) PubMed: 32461331

PAPER Kariolis MS, Wells RC, Getz JA, Kwan W, Mahon CS, Tong R, Kim DJ, Srivastava A, Bedard C, Henne KR, Giese T, Assimon VA, Chen X, Zhang Y, Solanoy H, Jenkins K, Sanchez PE, Kane L, Miyamoto T, Chew KS, Pizzo ME, Liang N, Calvert ME, DeVos SL, Baskaran S, Hall S, Sweeney ZK, Thorne RG, Watts RJ, Dennis MS, Silverman AP, Zuchero YJ

Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys.

Sci Transl Med. 2020 May 27;12(545) PubMed: 32461332

Postdoctoral Researcher in Behavior Genetics

JOB 2020-05-29 Employer University of California, San Diego Description UCSD is seeking a postdoctoral researcher in the Center for Behavior Genetics of Aging in the Department of Psychiatry. The successful applicant will work primarily on analyses and manuscript ...

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