COMMENT Both the Holtzman lab and our lab explored the role of microglia in mediating tau-induced neurodegenerative phenotypes in mice. Here, Shi et al. present exciting results of marked neuroprotection in a tau model after microglial ablation. In a different ...
RESEARCH NEWS 2019-10-17 Research News Researchers for years thought that tau was a natively unstructured protein. Then how in the world do its supposedly disordered monomers give rise to the orderly stacks of tau molecules seen in tau fibrils? Using chemical cross-linkers to ...
PAPER Popov KI, Makepeace KA, Petrotchenko EV, Dokholyan NV, Borchers CH
PAPER Brodie NI, Popov KI, Petrotchenko EV, Dokholyan NV, Borchers CH
Solving protein structures using short-distance cross-linking constraints as a guide for discrete molecular dynamics simulations.Sci Adv. 2017 Jul;3(7):e1700479. Epub 2017 Jul 7 PubMed: 28695211
RESEARCH NEWS 2019-10-17 Research News ApoE4 delivers a blow to neurons in mouse models of tauopathy but, according to a paper published October 10 in the Journal of Experimental Medicine, it only does so if mice have their microglia. Researchers led by David Holtzman at ...
THERAPEUTICS AstraZeneca Takeda Pharmaceutical Company Immunotherapy (passive) alpha-synuclein In October 2017, Astra Zeneca began a Phase 1 single-ascending-dose study in 48 healthy volunteers age 18 to 65. Each volunteer receives a one-hour intravenous infusion of ...
University College LondonLondon, United Kingdom
Technical University of Munich (TUM)München, Germany
Glen Iris, Australia
PAPER Smith R, Schöll M, Leuzy A, Jögi J, Ohlsson T, Strandberg O, Hansson O
Head-to-head comparison of tau positron emission tomography tracers [18F]flortaucipir and [18F]RO948.Eur J Nucl Med Mol Imaging. 2019 Oct 14; PubMed: 31612245
PAPER Pérez M, Amayra I, Martínez O, Lázaro E, López-Paz JF, García M, Berrocoso S, Al-Rashaida M, Rodríguez Bermejo AA, Luna PM, Varona Franco L
Signal-detection analysis of the WMS faces subtest: Results in amyotrophic lateral sclerosis patients.Appl Neuropsychol Adult. 2019 Oct 15;:1-7. PubMed: 31612730
PAPER McAdam RL, Morton A, Gordon SL, Alterman JF, Khvorova A, Cousin MA, Smillie KJ
Loss of huntingtin function slows synaptic vesicle endocytosis in striatal neurons from the httQ140/Q140 mouse model of Huntington's disease.Neurobiol Dis. 2019 Oct 12;:104637. PubMed: 31614197
PAPER Teo E, Ravi S, Barardo D, Kim HS, Fong S, Cazenave-Gassiot A, Tan TY, Ching J, Kovalik JP, Wenk MR, Gunawan R, Moore PK, Halliwell B, Tolwinski N, Gruber J
Metabolic stress is a primary pathogenic event in transgenic Caenorhabditis elegans expressing pan-neuronal human amyloid beta.Elife. 2019 Oct 15;8 PubMed: 31610847
PAPER Griner SL, Seidler P, Bowler J, Murray KA, Yang TP, Sahay S, Sawaya MR, Cascio D, Rodriguez JA, Philipp S, Sosna J, Glabe CG, Gonen T, Eisenberg DS31612856
PAPER Matyi JM, Rattinger GB, Schwartz S, Buhusi M, Tschanz JT31613825