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Fred van Leeuwen on Biogen/Eisai Halt Phase 3 Aducanumab Trials

COMMENT The next steps in curing Alzheimer’s disease Two decades ago, the late Dale Schenk initiated studies to treat AD patients by immunotherapy. Since then, an avalanche of clinical studies followed. Unfortunately, none of these trials proceeded beyond Phase 3 ...

Fred van Leeuwen on Ubiquitin Protease Implicated in Ataxia

COMMENT Ubiquitin Is Implicated Not Only at the End of the Chain of Neuropathological Events Most investigators think that ubiquitin, as a heat shock protein, is involved in reaction to neuronal damage. The results by Wilson et al. (Nature Genetics 2002), several ...

Fred van Leeuwen on Ubiquitin Protease Implicated in Ataxia

COMMENT The USP’s belong to the family of deubiquitinating enzymes (DUB’s) that are essential for subsequent proteasomal activity. The other family members are ubiquitin C-terminal hydrolases (UCH) that have been associated with Parkinson’s disease and gracile ...

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