3 RESULTS
COMMENT The paper by Olah et al. evaluates the microglial signature through scRNA-seq analyses of live microglia cells from 10 Alzheimer’s disease (AD), four mild cognitive impairment (MCI) and three temporal lobe epilepsy (TLE) patients and compares these data ...
COMMENT Thrupp et al. propose that snRNA-Seq technology fails to recapitulate microglia activation states in humans because activation genes are underrepresented in non-diseased human brains by snRNA-Seq. The paper reveals a difference in sensitivity between ...
COMMENT Takalo et al. present an interesting paper on an AD-associated protective variant in PLCG2 by making a Plcγ2-P522R knock-in (KI) mouse model. The authors showed that the Plcγ2-P522R mutation increased PLCγ signaling and promoted phagocytosis, survival, ...
