5 RESULTS
COMMENT This interesting study by Hu et al. presented two take-home messages. First, subpopulations of AD-reactive microglia are senescent. By studying the APP/PS1 mouse model, the authors showed that activated microglia proliferate around amyloid plaques, which ...
COMMENT Mer and Axl are phagocytic receptors expressed on microglia. During AD, Axl is highly upregulated in activated microglia, while Mer has a high baseline expression. In this exciting paper, Huang et al. presented provocative results showing that deficiency ...
COMMENT The paper by Olah et al. evaluates the microglial signature through scRNA-seq analyses of live microglia cells from 10 Alzheimer’s disease (AD), four mild cognitive impairment (MCI) and three temporal lobe epilepsy (TLE) patients and compares these data ...
COMMENT Thrupp et al. propose that snRNA-Seq technology fails to recapitulate microglia activation states in humans because activation genes are underrepresented in non-diseased human brains by snRNA-Seq. The paper reveals a difference in sensitivity between ...
COMMENT Takalo et al. present an interesting paper on an AD-associated protective variant in PLCG2 by making a Plcγ2-P522R knock-in (KI) mouse model. The authors showed that the Plcγ2-P522R mutation increased PLCγ signaling and promoted phagocytosis, survival, ...
