Marco Colonna, Yingyue Zhou on Single-nucleus RNA Sequencing Misses Activation of Human Microglia

COMMENT Thrupp et al. propose that snRNA-Seq technology fails to recapitulate microglia activation states in humans because activation genes are underrepresented in non-diseased human brains by snRNA-Seq. The paper reveals a difference in sensitivity between ...

Yingyue Zhou, Marco Colonna on Protective AD Variant Pinpoints Sweet Spot for Microglial Activation

COMMENT Takalo et al. present an interesting paper on an AD-associated protective variant in PLCG2 by making a Plcγ2-P522R knock-in (KI) mouse model. The authors showed that the Plcγ2-P522R mutation increased PLCγ signaling and promoted phagocytosis, survival, ...

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Marco Colonna, Yingyue Zhou on Single-nucleus RNA Sequencing Misses Activation of Human Microglia

Yingyue Zhou, Marco Colonna on Protective AD Variant Pinpoints Sweet Spot for Microglial Activation

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