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Weiming Xia on Linking APP to Apoptosis—p53 Does the Trick

COMMENT To keep apoptosis in check, it may be best to avoid the ups and downs of γ-secretase. Zebrafish lacking the γ-secretase component Pen-2 induce p53-dependent apoptosis throughout the body (Campbell et al., 2006), while mice lacking the Aph-1A component ...

Weiming Xia on SUMO-Wrestling with APP?

COMMENT The findings by Li et al. on the regulation of APP processing by sumoylation indeed bring a new perspective to the field of AD research. Although the authors documented a lack of direct sumoylation of APP and BACE, they have demonstrated a clear increase ...

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