13 RESULTS
COMMENT This is another pearl from the Yadong Huang lab at the Gladstone Institutes/UCSF cementing the hypothesis that neurons express ApoE, that this expression is genotype-dependent (APOE4 more expressed than APOE3), and that it is detrimental and linked to ...
COMMENT Brian Chow, Vicente Nuñez, and colleagues from Chenghua Gu’s lab at Harvard reveal the molecular mechanisms for a fascinating and fundamental feature of the brain vasculature: How do blood vessels “know” when neurons and other brain cells need more fuel ...
COMMENT This exciting study provides a comprehensive data resource on the molecular underpinnings of brain endothelial cell dysfunction. It builds on the group's prior work providing a healthy blood-brain barrier (BBB) transcriptome, an already incredibly ...
COMMENT Yin and co-workers describe a creative, novel approach to try to understand the physiological role of ApoE and its implications for Alzheimer’s and cardiovascular disease. Using ApoE-knockout and humanized ApoE3- and ApoE4-knock-in mouse models, they ...
COMMENT A great scientist, role model, and trail blazer in many respects has left us with Ben Barres. Ben was always very direct in his comments, critical or laudatory; he helped me look at my work more critically but he was also a big reason for me to stay at ...
COMMENT The results in this paper are interesting and possibly consistent with the seeding findings by Jucker and others. It would be interesting to see to what extent other (inflammatory) factors from the APP parabiont contribute to the amyloid and tau pathology ...
COMMENT Our article (Ray et al., 2007) gained a lot of attention, but it was very early days and we had to work with what was available. Our samples were from multiple centers, and the cases and controls were not perfectly matched for each. There was also a ...
COMMENT This report by Kodadek’s group describes a novel approach in the search for disease-specific molecular biomarkers. The authors are screening patient sera to find specific endogenous immunoglobulins that would be characteristic of a given disease. The ...
COMMENT The study presented by the Texas Alzheimer’s Research Consortium (TARC) is one in a series of recent publications supporting the concept that changes in the levels of blood-based proteins may be associated with Alzheimer disease and related conditions. ...
COMMENT The study by Nixon and colleagues is an absolutely gorgeous paper. It is cell biology at its best. It is interesting that our studies manipulating beclin-1 arrive at a very similar pathology as the lack of presenilin, both in vivo and in cell culture, ...
COMMENT The role of TNFα in the brain is complex. Although there is a lot of indirect evidence that TNFα is detrimental in AD, this protein can be neuroprotective and has been shown to mediate synaptic scaling, a process that helps cells to readjust synaptic ...
COMMENT Complement is activated in most forms of neurodegeneration and in AD in particular. Aβ aggregates (the particular conformation of which is ill-defined) can activate complement and may trigger the clearance of Aβ in solution via C3bi and complement ...
COMMENT Q&A with Tony Wyss-Coray. Questions by Tom Fagan. Q: In your recent paper, you show that TGF-β1 may offer protection against excitotoxic injury to neurons. In previous papers, you had seen evidence that the cytokine may be toxic. Do the present ...
