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Philip Wong on Remember: BACE2 Is in the Brain, Too

COMMENT This is a good study that raises the potential side effects of current BACE inhibitors (which do not discriminate BACE1 versus BACE2) due to impact on substrates of BACE2, particularly under pathological conditions. As it is not clear whether this ...

Philip Wong on Target BACE: Better Than Ever?

COMMENT Previous studies showed that the deletion of BACE1 abolished the production of Aβ and BACE1 knockout mice are apparently normal. In this current paper, Ohno et al tested whether cognitive deficits occurring in the mutant APP mice (Tg2576) can be ...

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