5 RESULTS
COMMENT The recent emphasis on Alzheimer’s disease drug development has produced therapeutics with promising results for various stages of pathology in AD mouse models, but unfortunately these strategies fail in human clinical trials. Using human iPSCs (hiPSC) ...
COMMENT In an elegant set of experiments, Herz and colleagues have continued to shed light on the role of reelin in synaptic function and provide further evidence for the protective nature of reelin against amyloid-associated synaptic plasticity and memory ...
COMMENT The elegant study by Rasgon and colleagues identifies yet another unknown consequence of ApoE4 expression: increased telomere (TL) shortening. Furthermore, this study suggests that hormone replacement therapy (HT) can effectively counteract these changes ...
COMMENT This paper by Hellwig et al. provides evidence to support yet another function for reelin in the CNS: presynaptic neurotransmitter regulation. The authors demonstrate that absence of reelin results in alteration in proteins involved in presynaptic ...
COMMENT The paper by Yadong Huang and colleagues describes the use of the well-established apolipoprotein E4 and E3 knock-in (KI) mice originally developed by Patrick Sullivan. The current research describes a significant decrease in GABAergic interneurons in the ...
