5 RESULTS
COMMENT Imaging synaptic density opens a new avenue to assess neurological conditions, in particular neurodegenerative conditions such as Alzheimer’s disease where a synaptopathy, either as a consequence of the toxic effects of aggregated proteins and/or other ...
COMMENT The data from Leal et al. help to bring clarity to the relationships between Aβ accumulation and the AV-1451 tau signal. On a relatively small number of cognitively normal 75 years old subjects, followed over five years, those who were accumulating Aβ, ...
COMMENT The latest entry in the roster of tau imaging agents is a 11 C tracer: 11 C-PBB3, based on a phenyl/pyridinyl-butadienyl-benzothiazoles/benzothiazoliums (PBBs) scaffold. These compounds are characterized by a π-electron-conjugated backbone with a specific ...
COMMENT We have seen in our AIBL study that 25 percent of cognitively unimpaired individuals with high Aβ burden in the brain have a significantly higher likelihood (odds ratio of 5) to show cognitive decline and progression to mild cognitive impairment and even ...
COMMENT The elegant report by Maeda and colleagues [1] shows that in vivo amyloid imaging with 11C-PIB in transgenic (Tg) mice is possible. After the initial in vivo studies with multiphoton microscopy showing binding of PIB to plaques in Tg mice [2], it was ...
