5 RESULTS
COMMENT We also have examined a LRKK2 frameshift variant (c.6187_6191delCTCTA; p.L2063fs*) in lymphoblastoid cell lines (LCLs) of an individual affected by amnestic MCI, without Parkinson’s disease (Perrone et al., 2018). The variant was a five-base-pair deletion ...
COMMENT As Carol Dobson-Stone and John Kwok mention, it is true that it is difficult to completely account for factors such as change in diagnostic techniques, better recognition of the disease by clinicians, or introduction of new environmental toxicants ...
COMMENT Several studies have been published on the clinical characteristics of fronto-temporal lobar degeneration (FTLD) patients carrying a C9orf72 repeat expansion since the discovery of the gene in 2011. In the March 2014 issue of JAMA Neurology, Devenney et ...
COMMENT I must say that this is a beautiful and incredibly extensive study that ties together many of the loose ends of the α-synuclein story. It is a scholarly example of how one and the same gene can either contribute 100 percent to disease causality or ...
COMMENT This is an unpleasant situation that is hindering Alzheimer research and progress. Progressing the field is what we promise to the patients and the families. A mutation that segregates in an early onset AD family is a major cause of grief to that family ...
