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Jon Valla on Does ApoE4 Risk Begin in the Womb?

COMMENT This interesting paper adds to the growing literature of brain imaging studies examining the effects of ApoE in young subjects. It is novel work in that it moves the imaging timepoint younger than the previous imaging studies performed mostly in young ...

Jon Valla on Does ApoE4 Lower Brain Metabolism Independently of Aβ?

COMMENT There is strong evidence that ApoE interacts with β amyloid to affect its aggregation and clearance, and this may be a major component of ApoE’s role in AD. That said, a number of other potential mechanisms may be involved in ApoE’s contribution to AD, ...

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