44 RESULTS
COMMENT Merrill et al. uncover the remarkable heterogeneity and brain-specific nature of lipoprotein particles (Lps) in the cerebrospinal fluid (CSF) of the human brain. To date, such CSF-Lps have remained understudied in comparison to the analogous lipoprotein p
COMMENT My lab has had a continued interest in the cell-type-dependent impact of APOE4 expression across the brain, particularly as it relates to lipid metabolism in glia. We have previously created isogenic iPSC lines bearing either the disease-neutral allele AP
COMMENT We appreciate Dr. Buzsaki’s interest in our work, where we and many others have shown that 40 Hz sensory stimulation ameliorates Alzheimer's pathology (Shen et al., 2022; Iaccarino et al., 2016; Singer et al., 2018; Park et al., 2020; Park et al., 20
COMMENT Following the posting of their preprint, Goate and colleagues have now published their work demonstrating enhanced cholesterol accumulation and decreased lipid clearance across astrocytes and microglia of APOE4 carriers. The work, which amongst its many i
COMMENT In this exciting paper from Tony Wyss-Coray's group at Stanford, researchers lead by Dr. Tal Iram found that cerebrospinal fluid isolated from young mice stimulates oligodendrocyte precursor proliferation and differentiation, and promotes myelination
COMMENT The authors report that microglial transcriptional heterogeneity, a measure of how well one has captured various microglial states, is quite poor across multiple brain regions, and between males and females, with the only biological factor strongly modula
COMMENT A large number of genetic risk factors have now been identified that alter risk for developing Alzheimer’s disease, however the mechanisms underlying their effects remain elusive in most cases. Cell-type contributions and sex-specific differences add addi
COMMENT This fascinating paper from the Huang lab describes a novel role for neuronal ApoE expression in Alzheimer’s disease. Zalocusky and colleagues find that neuronal ApoE is linked to immune response activation and selective neurodegeneration. Specifically, t
COMMENT Many thanks for putting together such a comprehensive review of GENUS work reported at ADPD. I’d like to add that three additional groups have independently replicated our preclinical data on GENUS. Park et. al. sought to determine whether treadmill exerc
COMMENT In this paper, Yang et al. present a novel method of labeling whole panels of plasma proteins to measure BBB permeability in the aging mouse. By labeling endogenous blood-plasma peptides, they were able to specifically measure physiological rates of plasm
COMMENT Based on the findings that theta/alpha (4-12 Hz) coherence is enhanced between brain areas during spatial memory tasks in rodents, one could hypothesize that disruptions in theta/alpha synchrony or coherence may occur in situations of memory dysfunction (
COMMENT High-salt diets have long been associated with increased risk for dementia. However, the underlying mechanisms have largely been unknown. Faraco and colleagues (Faraco et al., 2018) recently presented an intriguing mechanism in mice, showing that a high-s
COMMENT a co-author of this comment. lhtsai 0 REST and stress resistance in ageing and Alzheimer's disease. A C.
COMMENT Cortical organoids offer powerful technology for modeling brain development and other neurological disorders. However, cortical organoids have a high degree of inter-organoid variability, lack microglia and vascular cells, and often contain necrotic regio
COMMENT Wei-Ting and collaborators present, to the best of our knowledge, the first application of spatial transcriptomics and in situ sequencing to a murine model of Alzheimer’s disease (AD). This study, motivated by the empirical study of a complex “cellular ph
