Peter Todd on Make Proteins, Save Memory: The Cellular Stress Response and Synapses

COMMENT This paper provides additional data for the integrated stress response (ISR) as playing an active role in models of neurodegenerative disease. This response pathway both impacts protein synthesis and leads to stress-granule formation. Prior studies ...

Peter Todd on CRISPR Screen Pulls Down Fresh Targets for C9ORF72 ALS

COMMENT Here are my thoughts on the paper. This screen is specifically trying to identify toxicity from two DPRs: PR and, to a lesser extent, GR. It does not speak to toxicity from other DPRs or from the repeats as RNA and it does not look at modifiers of RAN ...

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Peter Todd on Make Proteins, Save Memory: The Cellular Stress Response and Synapses

Peter Todd on CRISPR Screen Pulls Down Fresh Targets for C9ORF72 ALS

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