48 RESULTS
COMMENT The new data from the Cruchaga lab are very intriguing and shine a particular spotlight on the role of CD33 in AD pathogenesis. We first described the genetic association of CD33 with AD risk in a family-based GWAS in 2008 (Bertram et al., 2008) and later ...
COMMENT In this interesting new study, Lopatko Lindman et al. examined the impact of antiviral treatment on long-term risk of dementia in a large Swedish registry-based cohort, focusing on herpes simplex virus (HSV) and varicella zoster virus (VZV), two highly ...
COMMENT Emerging evidence strongly supports that neural-glial interactions play a pivotal role in Alzheimer's disease pathogenesis. However, there are few human cellular models for studying these interactions. Lorenz Struder's team described a fully ...
COMMENT Bocharova et al. tested 5XFAD mice in an attempt to replicate our results demonstrating a protective role of Aβ against HSV1 (Eimer et al., 2018). Bocharova et al. present data intended to suggest the contrary; however, we do not believe their data ...
COMMENT In this study Schnier et al. examined four different European observational cohort studies for association between herpesvirus infection and dementia. Expanding upon the conclusions of Warren-Gash et al. that current published evidence is insufficient to ...
COMMENT Aducanumab was first developed by Roger Nitsch and Christoph Hock of Neurimmune when they started searching for naturally occurring autoantibodies to Aβ oligomers from memory B-cells of super agers. Roger is generous in his presentations to point out that ...
COMMENT Peter was clearly one of the greatest investigators in the pantheon of Alzheimer’s researchers. I knew him as a dear friend and valued mentor since the '80s. I always valued his great balance of scientific objectivity and empathy, especially for ...
COMMENT In this study, Pandey et al. report that a γ marker (GM) allotype more susceptible to HSV-1 immune evasion mechanisms is present at higher rates in subjects with Alzheimer’s disease. The authors show that carriers homozygous for the GM 17 allotype were ...
COMMENT For anyone interested, along the lines of this excellent new study, we also recently published a paper using family-based association to identify novel AD genetic risk factors that are sex-specific, in this case actually conferring opposite risk effects ...
COMMENT Using a mutant C9ORF72 mouse model, Burberry et al. report on the impact of the gut microbiome on disease progression in ALS. They show that fecal transplant using gut microflora from mice with loss of both (-/-) alleles of C9ORF72 raised in a protective ...
COMMENT Using a new, three-dimensional bioengineered human brain model, Cairns et al. report that HSV-1 infection induces pathological changes reminiscent of those observed in Alzheimer’s disease. This study is consistent with our previous publication, which ...
COMMENT This study is a step forward to a more physiologically relevant brain organoid model. Dr. Park’s team elegantly showed a vascularized human cortical organoid (vhCO), which displays blood-brain-barrier (BBB) characteristics and vasculature-like networks in ...
COMMENT This is another groundbreaking paper from the Arlotta lab. This study tackles a fundamental challenge of brain organoid models, “heterogeneity and reproducibility.” Since generation of organoids solely depends on the self-assembly and patterning capacity ...
COMMENT Ezzat et al. show that HSV1 accumulates a multiprotein corona, which they propose enhances infectivity. The authors present data showing Aβ binds HSV1 and RSV, and that the binding induces fibrillization of the peptide. We have previously shown that Aβ ...
COMMENT This study describes a toolkit for studying neurofibrillary inclusion and Lewy body formation in an in vivo-like murine environment. Organotypic brain slice cultures have been used to study brain cells ex vivo for more than a decade. Multiple tauopathy ...
