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Rudy Tanzi on LOADed ADAM 10 Mutations Bolster Amyloid Hypothesis

COMMENT We would like to address the concern of Drs. Postina and Kojro, who questioned whether increased Aβ levels in the ADAM10 X Tg2576 mouse brains could be due to differences in ADAM10 expression versus effects of the ADAM10 LOAD mutations. We refer to Figure ...

Rudy Tanzi on Presenilin Loss of Function—Plan B for AD?

COMMENT In the field of genetics, it is a rare and precious opportunity that we are afforded as scientists, when we can assess the effects of multiple mutations in multiple genes leading to common clinical and pathological disease phenotypes. We have this ...

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