20 RESULTS
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COMMENT In this manuscript, Hoover and colleagues report that overexpressed tau distributes to dendritic spines, where it impairs synaptic responses. The results suggest that not only does tau lead to pre-synaptic dysfunction by impairing axonal transport, but it ...
COMMENT This manuscript is very interesting. Mandelkow’s group basically has studied many aspects of tau, such as the structure, aggregation mechanism, phosphorylation kinases, and inhibitory effect of tau on axonal transport. But the mechanism of missorting of ...
COMMENT In this manuscript, Ittner and colleagues showed that tau has a role in Aβ toxicity, which may be different from the role of tau on microtubules. Interaction of tau and Fyn is required for stabilizing the NR2/PSD95 complex. Reduction of tau, or ...
COMMENT Tackenberg and Brandt showed that Aβ is involved in synapse loss, and that hyperphosphorylated tau is involved in neuronal death, using primary neuronal cultures. However, there are discrepancies from our previous report analyzing wild-type human tau Tg ...
COMMENT This is quite an interesting paper. Abramov and colleagues carefully investigated the role of Aβ in presynaptic function, and found that Aβ works as a positive regulator of transmitter release. This is the first report on a physiological role of Aβ as far ...
COMMENT This is a very interesting paper. It indicates that a new tau isoform, other than the conventional 6 isoform, plays an inhibitory role in tau aggregation. If we could regulate the expression of this alternative splicing by a chemical compound, and ...
COMMENT In this paper, Randy Nixon’s group first demonstrated in vivo that axonal transport rates are not significantly affected by tau deletion or overexpression in mouse brain. The results are highly convincing. In in vitro studies, the Mandelkows’ group and ...
COMMENT We know, based on Mandelkow’s and Hirokawa’s work, that accumulation of tau in neurons inhibits axonal transport, and may affect synaptic function. Hyperphosphorylation of tau detaches tau from microtubules, and restores axonal transport. However, ...
COMMENT In this paper, Luo and colleagues showed that PU24FCI inhibited Hsp90 activity and accelerated tau degradation. It is quite surprising that this drug treatment in JNPL3 mice reduced the amount of sarcosyl-insoluble tau within hours. This result suggests ...
COMMENT How Might Presenilin-1 (PS1) Mutations Induce Early Onset Alzheimer Disease? Shen and Kelleher have suggested that presenilin dysfunction can cause AD phenotypes, because they found that presenilin double knockout mice exhibited synaptic dysfunction, tau ...
COMMENT King and colleagues expanded on a previous report by Rapport and colleagues that showed that tau is essential for β amyloid-induced neurotoxicity. In this report, King et al. show that a prefibrillar form of Aβ induced tau-dependent microtubule ...
COMMENT Boekhoorn and colleagues indicated that their P301L tau transgenic mice showed higher LTP and memory performance when they are young—before NFTs and hyperphosphorylation have occurred yet. But Mandelkow’s group found that tau overexpression inhibits the ...
COMMENT Epidemiological studies indicate that populations taking anti-inflammatory drugs have a significantly reduced prevalence of AD, or a slower mental decline (McGeer et al., 1998). This paper demonstrated how inflammation due to microglial activation might ...
COMMENT SantaCruz and colleagues manipulated transgenic tau levels using the tet-off system. Their results indicate that NFT accumulation is not sufficient to cause neuronal death and cognitive decline. This result was a bit of a surprise, because NFT formation ...
COMMENT I read Yong Shen's review on molecular events of neuron death in AD, and the comments, with great interest. As Paul mentioned, neuron death is a consequence of what happened in neurons in AD. I agree, but even after the horse is gone footprints and ...
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