11 RESULTS
COMMENT This study is very interesting, extending to human cohort data previously reported in murine models. We recently showed that TgCRND8 mice whose diet was supplemented with the plant polyphenol oleuropein aglycone found in olive leaves and in olive oil ...
COMMENT The theme of selective cell vulnerability in neurodegenerative (but also in other amyloid) diseases is of the utmost importance to better understand the molecular basis of the pathological aggregate-cell interaction and its consequences. Most data so far ...
COMMENT The issue covered in this article is very interesting and reconciles many previous data on amyloids in general and on Aβ peptides in particular. In general, it has been reported that a variant of SAA (serum amyloid A), whose aggregates are involved in a ...
COMMENT The data reported in this exciting paper can potentially open new ways to interpret AD pathogenesis at the molecular level. Of course, much more data are needed to assess the relevance for AD of the APP-DR6 interaction; however, when confirmed, such a new ...
COMMENT This is a very important paper illustrating for the first time at high resolution the relation between Abeta oligomers and the condition of dendritic spines in a highly significant animal model of AD. Obviously, several points remain to be addressed, for ...
COMMENT Several recently appeared papers on the AD-Ca2+ relation have undoubtedly shown that the issue has come to ripeness. The data showing a significant increase of free Ca2+ inside neurons close to amyloid plaques, coupled with neuronal degeneration and ...
COMMENT The work by Bezprozvanny and colleagues undoubtedly adds considerably new information about the physiological function of presenilins as well as on their possible roles in AD pathogenesis at the molecular level. These data also add knowledge on the ...
COMMENT The theme of the differential susceptibility of different cell types to toxic amyloid aggregates is of outstanding importance. We have recently carried out research where we investigated the different impairment of cell viability in a wide panel of ...
COMMENT The paper by Darios and Davletov provides significant information on the triggers of cell membrane expansion underlying neurite outgrowth. The importance of omega-3 and omega-6 polyunsaturated fatty acids in enabling syntaxin 3 to complex with SNAP25 ...
COMMENT The background article by Brian Balin on the possible microbial cause of Alzheimer disease (AD) and, possibly, other degenerative diseases is intriguing and I think the microbial origin must be taken into consideration at least as a possible con-cause in ...
COMMENT Indeed, since some time I have been thinking about the need to search for protofibril stabilizers, i.e., substances, possibly but not necessarily amphipathic, able to interact with early oligomers of misfolded proteins or peptides by masking their exposed ...
