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Tara Spires-Jones on Do Tribes of Astrocytes Wage War on Synapses?

COMMENT The finding by Miller et al. that a subset of mouse cortical astrocytes secrete Norrin, which is important for dendritic spine integrity, is very interesting. Synapse loss is the strongest pathological correlate of cognitive decline in Alzheimer’s disease ...

Tara Spires-Jones on Tau (Alz50)

COMMENT This antibody recognizes a folded conformation of tau containing amino acids 2-10 and 312-342. We have used it successfully to detect misfolded tau in mouse models of tauopathy using array tomography, a relatively new imaging technique (Kopeikina et al., ...

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