David Sinclair on Sirtuin Inhibitor Boosts Cognition, Reduces Phospho-tau
COMMENT One must be careful when calling nicotinamide an "inhibitor" in this experiment. While it is true that our lab showed that nicotinamide is a direct inhibitor of SIRT1 enzyme, it is also a precursor of NAD+, and NAD+ is a co-substrate (i.e., ...