13 RESULTS
COMMENT These reports by Ayalon and Zilkova are helpful to the field of tau immunotherapy. It is interesting that they do not reach the same conclusion regarding the importance of antibody effector function for microglial phagocytosis. Similar differences between ...
COMMENT The extensive data in this article is an outstanding resource for the field. It nicely confirms several known features of the progression of tauopathy in AD and adds new information to refer to for ongoing and future studies. With regard to therapies, I ...
COMMENT These are interesting and rather compelling findings. It is nice to see that antibody-mediated targeting of phospho-tau epitopes, as we have advocated, was most effective under these conditions. It is notable that the phospho-epitopes identified by mass ...
COMMENT This article describing the structure and binding properties of the CBTAU-24.1 antibody is a nice addition to similar reports in recent years of various tau antibodies against different epitopes. It would be informative to know if this antibody is the ...
COMMENT These are carefully conducted and informative measurements by a stellar group of investigators. It will be interesting to see how the tau antibodies in clinical trials may influence tau levels in CSF and plasma, which may differ to some extent between AD ...
COMMENT We read this paper with interest. Because the authors reference our work critically, we would like to clarify the points raised by the authors, specifically neuronal uptake of tau antibodies and the presence of Fc receptors on neurons. We do not dispute ...
COMMENT This interesting article relates nicely to our work with tau antibody and its single chain variable fragment (Krishnaswamy et al., 2014). einar.sigurdsson 0 Antibody-derived in vivo imaging of tau pathology. ...
COMMENT We thank Rakez for his comment. Antibody response towards non-phosphorylated regions of the immunogen can be expected considering its length and immunogenicity. This should not cause major concerns, as we address in the fourth paragraph of the Discussion ...
COMMENT Clavaguera and colleagues demonstrate in this elegant study that an injection of a brain extract from P301S tau mice induces aggregation of wild-type tau in mice expressing human or mouse tau. The pathology spreads to anatomically connected brain regions ...
COMMENT Andre Delacourte raises a good question about extracellular versus intracellular clearance. It is certainly possible that extracellular tangles may be cleared, but we show that intraneuronal tau aggregates are targeted as well. The paper discusses this in ...
COMMENT The study by Racke and colleagues is the third report showing cerebral bleeding in different AD mouse models following passive immunization with monoclonal antibodies with high affinity for Aβ plaques and congophilic angiopathy (Pfeifer et al., 2002; ...
COMMENT This is an elegant study that shows the importance of studying further the biological role of PrPC, and the intermediates that are formed during the conversion of PrPC to PrPSc. It is interesting to compare these findings to the Alzheimer's field, ...
COMMENT The study by Paramithiotis and colleagues is meticulously performed and demonstrates that animals immunized with the Tyr-Tyr-Arg repeat motif of the prion protein (PrP) generate antibodies that selectively recognize the scrapie form of PrP. Surprisingly, ...
